Probiotic Microorganisms for Skin Flora Stabilization
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Solution Overview
Problem
The human skin is vulnerable to colonization by pathogenic microorganisms, particularly after disruptions such as antibiotic use or excessive washing, which can lead to an imbalance in the natural skin flora, compromising the skin's protective barrier and increasing the risk of infections.
Innovation Solution
The use of specific microorganisms, such as Lactobacillus species, that stimulate the growth of resident skin microbial flora while inhibiting the growth of transient pathogenic microorganisms, thereby restoring and stabilizing the natural skin flora and preventing pathogenic colonization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If antibiotics or excessive washing are used to treat skin conditions, then the skin surface is cleaned or infections are reduced, but the resident skin flora is damaged and pathogenic microorganisms can colonize
Solution Approach 1:
The patent uses specific microorganisms (Lactobacillus species and other probiotics) as intermediary agents to restore and stabilize the resident skin flora. These probiotic microorganisms act as mediators that compete with pathogenic microorganisms for attachment sites and nutrients, thereby preventing pathogenic colonization without requiring antibiotics that would further damage the skin barrier.
Solution Approach 2:
The invention enables the skin's natural protective mechanism to recover by introducing microorganisms that stimulate the growth of resident skin flora. The probiotics self-organize to restore the natural microbial balance, allowing the skin barrier to regain its protective function through biological self-regulation rather than continuous external intervention.
2Reliability
If the resident skin flora is stimulated to grow, then protection against pathogenic microorganisms is enhanced, but additional microorganisms are introduced to the skin
Solution Approach 1:
The patent changes the composition parameters of the skin microbiome by introducing specific probiotic microorganisms that selectively stimulate the growth of beneficial resident flora while inhibiting pathogenic species. This parameter change in microbial composition restores the natural protective barrier without creating uncontrolled microbial diversity, as the probiotics establish a stable, beneficial microbial ecosystem.
3Object-affected harmful factors
If pathogenic microorganisms are allowed to attach to skin structures, then colonization occurs, but the skin's natural attachment sites are occupied by harmful agents
Solution Approach 1:
The patent applies preliminary anti-action by introducing probiotic microorganisms that preemptively occupy attachment sites on skin structures before pathogenic microorganisms can colonize. The probiotics establish themselves first, creating a protective layer that prevents pathogenic attachment through competitive exclusion, thereby maintaining the stability of the skin microbial flora composition.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively protects the skin against pathogenic microorganisms by regenerating and stabilizing the natural skin flora, reducing the risk of infections and maintaining the skin's barrier function.
Implementation Method 1
The use of specific microorganisms, such as Lactobacillus species, that stimulate the growth of resident skin microbial flora while inhibiting the growth of transient pathogenic microorganisms
Implementation Method 2
The microorganisms of the resident skin flora prevent the colonization by pathogenic microorganisms by competing for attachment sites and essential nutrients on the skin surface
Implementation Method 3
the organisms of the resident skin flora are able to produce antimicrobial substances to fight against pathogenic microorganisms
Data Source
AI summary
Described are microorganisms which are, in a first aspect, able to to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora. In a second aspect microorganisms are described which are able to inhibit the growth of microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the resident skin micro flora. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.