Probiotic Strain Combination for Stress-Related Cognitive and Mood Support
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Solution Overview
Problem
There is a need for alternative compositions effective in the prevention and/or treatment of acute or chronic conditions linked to stress, such as impairment of cognitive functions, anxiety, insomnia, baby blues, post-partum depression, menopausal depression, generalized anxiety disorder, major depressive disorder, and panic attacks, which existing probiotic formulations have not adequately addressed.
Innovation Solution
Compositions comprising a probiotic combination of Lactobacillus reuteri PBS072 in association with Bifidobacterium breve BB077 or Bifidobacterium lactis BL050, formulated in various forms for oral administration, to improve cognitive functions, reduce stress-related symptoms, and treat conditions like baby blues and post-partum depression.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing probiotic formulations are used, then general probiotic benefits are provided, but they fail to adequately address stress-related conditions and cognitive impairment
Solution Approach 1:
The patent combines three specific probiotic strains (Lactobacillus reuteri PBS072, Bifidobacterium breve BB077, and Bifidobacterium lactis BL050) into a single formulation. This merging of multiple strains with complementary functions creates a synergistic effect that addresses multiple stress-related conditions simultaneously, resolving the contradiction between reliability for specific conditions and versatility across different pathologies.
Solution Approach 2:
The probiotic composition functions as a composite biological material where each strain contributes specific properties: L. reuteri PBS072 provides stress reduction capabilities, B. breve BB077 contributes to cognitive function support, and B. lactis BL050 enhances mood regulation. This composite approach enables the single formulation to reliably treat multiple stress-related conditions with different mechanisms of action.
2Reliability
If single-strain probiotics are used, then the formulation is simple, but the therapeutic effect on complex stress-related conditions is insufficient
Solution Approach 1:
The patent merges three probiotic strains into one integrated formulation, achieving reliable therapeutic effects on complex stress-related conditions while maintaining formulation simplicity. The combined action of L. reuteri PBS072, B. breve BB077, and B. lactis BL050 produces synergistic benefits that exceed the sum of individual strain effects, addressing cognitive impairment, anxiety, and mood disorders more effectively than single-strain alternatives.
3Reliability
If probiotic compositions are administered, then stress markers are reduced and cognitive functions improve, but the mechanism of action needs to be clearly understood
Solution Approach 1:
The patent employs multiple assessment methods to detect and measure the mechanism of action: cognitive function tests, mood assessments, stress marker measurements, and gut microbiota analysis. These feedback mechanisms provide comprehensive data on how the probiotic composition affects brain-gut axis communication, neurotransmitter production, and stress response pathways, making the previously difficult-to-measure mechanisms observable and quantifiable.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The probiotic compositions significantly improve cognitive functions, reduce stress markers, enhance mood, and improve sleep quality by modulating neurotransmitters and enzymes involved in stress response, demonstrating efficacy in clinical studies on students, employees, and post-pregnancy women.
Implementation Method 1
The probiotic compositions significantly improve cognitive functions, reduce stress markers, enhance mood, and improve sleep quality by modulating neurotransmitters and enzymes involved in stress response
Data Source
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AI summary
The present invention relates to compositions comprising a probiotic combination comprising a strain belonging to the Lactobacillus reuteri species in association with a strain belonging to the Bifidobacterium genus selected from the species: Bifidobacterium breve or Bifidobacterium lactis. These compositions are useful in the prevention and/or treatment of acute or chronic stress-related pathological conditions selected from the group comprising impairment of cognitive function, insomnia, anxiety, baby blues and post- partum depression, menopausal depression, generalized anxiety disorder, major depressive disorder, panic attacks, attention deficit disorder or combinations thereof.