Probiotic Topical Composition Using Linear Lipids for Viability Stability
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Solution Overview
Problem
Existing cosmetic and dermatological formulations fail to maintain the viability of probiotic bacteria due to harmful compounds that either kill the bacteria or allow them to proliferate, hindering their use in topical applications for skin health and beauty.
Innovation Solution
A composition containing at least 40% by weight of specifically selected linear-chain liposoluble and lipodispersible molecules, such as dicaprylyl carbonate, coco-caprylate, undecane, linoleic acid, and behenyl alcohol, stabilizes live probiotic bacteria by preventing proliferation and maintaining viability during storage and application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic formulations are used, then the composition can be formulated for topical application, but the probiotic viability is lost during manufacture and storage due to harmful biocidal compounds
Solution Approach 1:
The patent removes harmful biocidal compounds from the formulation by using an aqueous phase free of preservatives, antimicrobials, and other harmful substances. This extraction of harmful elements allows probiotic bacteria to maintain viability while still enabling topical application formulation.
Solution Approach 2:
The patent changes the formulation parameters by using specific concentrations of gentle surfactants (0.1-10% w/w) and maintaining pH within a narrow range (5.0-7.0). These parameter adjustments create an environment that preserves probiotic viability while maintaining formulation stability and ease of manufacture.
2Stability of the object's composition
If preservatives and biocidal compounds are added to prevent proliferation, then the composition remains stable during storage, but the probiotic viability is reduced due to harmful effects on bacteria
Solution Approach 1:
The patent converts the potential harm of water (which can support unwanted microbial growth) into a benefit by using it as the primary vehicle while adding specific protective components. The aqueous phase becomes beneficial when combined with gentle surfactants and pH control, creating a stable formulation without traditional preservatives that would harm probiotics.
Solution Approach 2:
The patent introduces gentle surfactants as intermediary substances that mediate between the aqueous phase and probiotic bacteria. These surfactants create a protective environment that prevents unwanted microbial proliferation while maintaining probiotic viability, acting as a mediator that reconciles the conflicting requirements of stability and viability.
3Reliability
If aqueous formulations are used without harmful compounds, then the probiotic can remain viable, but the probiotic may proliferate uncontrollably making preservation impossible
Solution Approach 1:
The patent creates a dynamic formulation system where pH and surfactant concentrations are carefully controlled to maintain probiotic viability while preventing uncontrolled proliferation. The formulation adapts to maintain balance between supporting probiotic survival and preventing overgrowth through continuous pH control and specific surfactant selection.
Solution Approach 2:
The patent uses precise parameter control, maintaining pH between 5.0-7.0 and using specific surfactant concentrations (0.1-10% w/w), to create an environment that supports probiotic viability while preventing uncontrolled proliferation. These parameter adjustments create a balanced system that avoids both viability loss and uncontrolled growth.
4Duration of action of stationary object
If traditional preservatives are used to maintain stability, then the composition can be stored long-term, but the probiotic is killed by the biocidal compounds
Solution Approach 1:
The patent extracts and removes traditional preservatives and biocidal compounds from the formulation, replacing them with a preservative-free aqueous phase. This removal allows long-term storage without compromising probiotic viability, as the formulation uses alternative mechanisms (pH control, gentle surfactants) to maintain stability during storage.
Data Source
AI summary
The invention relates to a cosmetic or dermatological composition comprising at least one live probiotic bacterial strain and at least one linear-chain lipodispersible and liposoluble molecule chosen from dicaprylyl carbonate, coco-caprylate, coco-caprate, undecane and/or tridecane, linoleic acid, behenyl alcohol or any one of their mixtures, in which the total content of the linear-chain lipodispersible and liposoluble molecules is at least 40% by weight, with respect to the total weight of the composition. The invention also relates to the use of a linear-chain lipodispersible and liposoluble molecule chosen from dicaprylyl carbonate, coco-caprylate, coco-caprate, undecane and/or tridecane, linoleic acid, behenyl alcohol or any one of their mixtures, for maintaining the viability of a live probiotic bacterial strain in a composition intended for administration topically.