Probiotic and Vitamin C Antioxidant Composition

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Solution Overview

Problem

Current antioxidant compositions fail to effectively prevent skin aging and oxidative stress, as they do not adequately address the production of reactive oxygen species and the resulting cellular damage, despite studies on vitamin C and probiotics showing promise.

Innovation Solution

A composition combining probiotics, specifically lactic acid bacteria strains like Enterococcus faecium and Lactobacillus rhamnosus, with vitamin C, which enhances antioxidant enzyme activity and synergistically increases antioxidant effects, thereby reducing reactive oxygen species and improving skin conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If vitamin C alone is used as antioxidant, then antioxidant effect is provided, but insufficient removal of reactive oxygen species occurs

Engineering Contradiction:
Improveantioxidant effectVSAvoidremoval of reactive oxygen species
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent combines vitamin C with probiotics (specifically Lactobacillus casei strain Shirota) to create a synergistic antioxidant system. The probiotics enhance the antioxidant effect by producing additional antioxidants and enzymes that work together with vitamin C to more effectively remove reactive oxygen species, thereby resolving the insufficiency of vitamin C alone.

Inventive Principle:
Principle #5Merging (Combining)

2Productivity

If probiotics are added to enhance antioxidant effect, then synergistic removal of reactive oxygen species is achieved, but complexity of composition increases

Engineering Contradiction:
Improveremoval of reactive oxygen speciesVSAvoidcomposition structure
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The probiotic component serves multiple functions: it acts as an antioxidant itself, produces enzymes that eliminate reactive oxygen species, and enhances the stability and efficacy of vitamin C. This multi-functionality allows a single ingredient (probiotic) to address multiple aspects of the antioxidant system, reducing the need for additional separate components.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Reliability

If higher doses of vitamin C are used to improve antioxidant effect, then antioxidant activity increases, but side effects and loss of substance occur

Engineering Contradiction:
Improveantioxidant activityVSAvoidvitamin C degradation
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The probiotic acts as an intermediary that enhances the antioxidant system's efficiency. By introducing probiotics that produce their own antioxidants and enzymes, the system achieves higher antioxidant activity at lower vitamin C concentrations, reducing direct oxidation and degradation of vitamin C while maintaining effectiveness.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of probiotics and vitamin C significantly increases antioxidant activity, improving skin health by reducing oxidative stress, enhancing physical ability, and promoting weight loss, while maintaining the viability and effectiveness of the probiotics.

Implementation Method 1

L-ascorbic acid (vitamin C) is a typical antioxidant substance together with flavonoids and Carotenoid glutathione, is essential for the human body, and acts to keep reactive oxygen species in the body always at a constant level.

Methodology Applied
Scientific EffectAntioxidant effect: Oxidation

Implementation Method 2

a composition containing probiotics in addition to vitamin C induces the activity of antioxidant enzyme to exhibit a synergistic effect on removal of reactive oxygen species

Methodology Applied
Scientific EffectEnzyme activity: Enzyme

Data Source

PatentEP3318263B1Antioxidant composition and composition for improvement of skin conditions
Publication Date: 2021.10.06 CELL BIOTECH CO LTD
  • EP3318263B1 patent drawingFigure 1~2
  • EP3318263B1 patent drawingFigure 3~4
  • EP3318263B1 patent drawingFigure 5

AI summary

The present invention provides an antioxidant composition and/or a composition for improving skin conditions, which contain, as active ingredients, probiotics and vitamin C. The composition containing probiotics and vitamin C as active ingredients according to the present invention can exhibit a synergistic effect on the activation of antioxidant enzyme, thereby exhibiting an antioxidant effect and a skin condition improving effect. In addition, the composition containing probiotics and vitamin C as active ingredients according to the present invention can more effectively induce antioxidant effects to activate energy metabolism in vivo, thereby exhibiting a significant synergistic effect on weight loss.