Probiotic Vitamin D3 Composition for Faster Serum Absorption
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Solution Overview
Problem
Current treatments for vitamin D deficiency and insufficiency are ineffective in rapidly increasing vitamin D absorption and bioavailability, particularly in subjects with sterol absorption issues, and can lead to increased blood cholesterol levels.
Innovation Solution
A specific bacterial strain, Lactobacillus paracasei DG ®< CNCM I-1572, is administered simultaneously with vitamin D, preferably vitamin D3, to enhance vitamin D absorption and bioavailability in the bloodstream, while avoiding increased cholesterol levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional vitamin D treatments are administered, then vitamin D levels should increase, but the absorption and bioavailability increase slowly and ineffectively
Solution Approach 1:
The patent introduces a specific bacterial strain (Lactobacillus reuteri NCIMB 30242) as an intermediary agent that mediates between administered vitamin D and the host's absorption systems. This probiotic strain enhances the bioavailability and absorption rate of vitamin D through microbial-metabolic interactions in the gut, thereby accelerating the therapeutic effect without compromising safety
Solution Approach 2:
The patent changes the physiological parameters of the digestive system by introducing specific bacterial strains that modify the gut environment. These parameter changes include alterations in gut pH, enzymatic activity, and microbial metabolism, which collectively enhance vitamin D solubility, stability, and absorption efficiency, leading to faster therapeutic responses
2Productivity
If vitamin D treatments are administered to subjects with sterol absorption issues, then vitamin D absorption should improve, but cholesterol levels may increase
Solution Approach 1:
The patent extracts and isolates a specific probiotic bacterial strain (Lactobacillus reuteri NCIMB 30242) that has been specifically selected for its ability to enhance vitamin D absorption without the side effect of increasing cholesterol levels. This extracted strain is then used in controlled formulations to treat vitamin D deficiency while avoiding the harmful cholesterol elevation associated with conventional treatments
Solution Approach 2:
The patent employs a transient probiotic intervention using a specific bacterial strain that temporarily enhances vitamin D absorption during the treatment period. The probiotic acts as a short-term facilitator that can be discontinued once therapeutic levels are achieved, avoiding long-term exposure that might lead to cholesterol accumulation
Data Source
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AI summary
The present invention relates to bacterial strains for use in the treatment of vitamin D deficiency and/or insufficiency and/or diseases, symptoms and/or disorders associated thereto. Furthermore, the present invention relates to compositions comprising at least one of said bacterial strains and at least one vitamin D, preferably vitamin D3, and to the use thereof in the treatment of said vitamin D deficiency and/or insufficiency and/or diseases, symptoms or disorders associated thereto.