Prohexadione Ionic Liquid Concentrate Stability

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Solution Overview

Problem

Existing plant growth regulator (PGR) concentrates, particularly those containing prohexadione, face challenges due to its limited water solubility and stability, making it difficult to formulate stable and effective concentrates for agricultural use.

Innovation Solution

A liquid concentrate is developed using prohexadione dissolved in an ionic liquid comprising an organic base and a strong acid, which provides enhanced stability and solubility, allowing for the inclusion of additional active compounds and additives.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If prohexadione is supplied as a concentrated solution in water, then ease of manufacture and application is improved, but stability and solubility deteriorate

Engineering Contradiction:
Improveease of manufactureVSAvoidstability
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent changes the solvent parameter from water to an organic solvent (ethanol or propanol), which fundamentally alters the solubility and stability characteristics of prohexadione. This parameter change enables the active substance to maintain both high solubility and long-term stability in the concentrate formulation.

Inventive Principle:
Principle #35Parameter changes

2Ease of operation

If prohexadione is supplied as a dispersion in water, then ease of mixing is improved, but solubility and homogeneity deteriorate

Engineering Contradiction:
Improveease of mixingVSAvoidhomogeneity
Core Design Contradiction:
Ease of operationVSStability of the object's composition

Solution Approach 1:

The patent changes the physical state parameter of the active substance from suspended particles in a dispersion to completely dissolved molecules in a true solution. This is achieved by changing the solvent parameter to an organic solvent, resulting in a homogeneous concentrate that mixes easily with water while maintaining complete dissolution of prohexadione.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If high concentration of active substance is used, then productivity is improved, but solubility deteriorates

Engineering Contradiction:
ImproveproductivityVSAvoidsolubility
Core Design Contradiction:
ProductivityVSQuantity of substance

Solution Approach 1:

The patent changes the solvent parameter to an organic solvent (ethanol or propanol) which has significantly higher solubility capacity for prohexadione compared to water. This enables the formulation of concentrates with high active substance content (5-25% or higher) while maintaining complete solubility and stability, thereby improving productivity without sacrificing solubility.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ionic liquid formulation ensures the stability of prohexadione, enabling high-concentration liquid formulations that are easily dispersible in water, thus offering improved efficacy and extended storage stability.

Implementation Method 1

A liquid concentrate is developed using prohexadione dissolved in an ionic liquid comprising an organic base and a strong acid, which provides enhanced stability and solubility

Methodology Applied
Scientific EffectSolvation: Solvation

Data Source

PatentUS12239131B2Plant growth regulator concentrate and use thereof
Publication Date: 2025.03.04 FINE AGROCHEMICALS LTD

AI summary

The invention relates to a liquid concentrate comprising a plant growth regulator like prohexadione dissolved in an ionic liquid, the ionic liquid comprising an organic base and a strong acid. The ionic liquid may comprise an amine, amide, imine, imide or urea. The strong acid preferably is ethephon.