Prohormone Delivery via Enzymatic Conversion to Reduce Side Effects
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Solution Overview
Problem
Existing methods for delivering hormones and longevity-enhancing therapies often result in undesired side effects due to hormonal imbalances and inefficient absorption, particularly in the gastrointestinal tract.
Innovation Solution
A system and method combining rapamycin, a prohormone, and cannabidiol (CBD) to enhance cellular regeneration, mitochondrial activity, and targeted hormone delivery, utilizing oral, topical, or injectable formulations to improve absorption and minimize side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If hormones are delivered through injection to ensure rapid delivery, then the speed of hormone delivery is improved, but harmful factors increase due to hormonal imbalances and undesired side effects at inappropriate sites
Solution Approach 1:
The hormone delivery system is segmented into multiple components: a prohormone that is converted locally by enzymatic action at target sites, rather than delivering active hormone systemically. This segmentation allows the hormone precursor to be delivered safely through circulation and converted to active form only where needed, reducing side effects while maintaining delivery speed
Solution Approach 2:
An enzymatic conversion process acts as an intermediary between hormone delivery and target site activation. The prohormone serves as an intermediate form that circulates safely, then undergoes enzymatic transformation at the target tissue to produce the active hormone locally, mediating between rapid delivery and selective action
2Object-affected harmful factors
If the digestive system is used for hormone delivery to avoid injection side effects, then harmful factors are reduced, but absorption efficiency decreases
Solution Approach 1:
The chemical parameters of the hormone delivery system are changed by using a prohormone form with different stability and absorption characteristics than the active hormone. The prohormone is designed to resist degradation during gastrointestinal passage while maintaining bioavailability, then undergoes conversion to the active form at the target site, optimizing both safety and absorption
3Productivity
If cells specialize in specific tasks to maximize efficiency, then productivity is improved, but adaptability decreases when hormonal signals reach inappropriate sites
Solution Approach 1:
The hormone delivery system implements local quality by ensuring that active hormone is produced only at specific target sites through localized enzymatic conversion of the prohormone. Different tissues have different enzymatic capabilities, creating site-specific activation patterns that match cellular specialization while preventing inappropriate responses in non-target tissues
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of rapamycin, prohormone, and CBD improves health and longevity by enhancing cellular regeneration, mitochondrial activity, and targeted hormone delivery, reducing the risk of side effects and improving overall quality of life.
Implementation Method 1
Biodelivery/availability of the rapamycin and prohormone is improved using a cannabinoid substance, preferably CBD or a derivative to target delivery to intestinal mucosa and/or improve buccal uptake
Data Source
AI summary
The present invention discloses a system and method for preparing and delivering health and longevity compositions. This invention is designed to improve the quality of life and lifespan of mammals. Compositions of the present invention are selected and designed for the purpose of efficiently delivering health and longevity enhancing therapies through oral supplementation; misting; nasal spray; intravenous, IM, and/or sub-cutaneous, injection; suppository; etc. A non-toxic therapeutic anabolic hormone replenishment is combined with rapamycin and cannabidiol. The three compounds work together to improve quality of life and healthy lifespan. Preferred additional supplements may include metformin, growth hormone, and/or supplemented minerals. A preferred embodiment features low dose continuous supplementation, e.g., incorporated with daily meals. Processes of the present invention delivers an orally ingested substance, e.g., a snack, a human food supplement, an animal treat, etc., that contains the active compounds to be absorbed by the digestive system or delivered into the bloodstream.