Silica-Based Propandiol Mononitrate Formulation With Native Starch Retention

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Solution Overview

Problem

Propandiol mononitrate and its derivatives are not effectively retained under conventional storage conditions, particularly when absorbed onto standard carrier systems used in the feed industry, leading to storage instability and increased costs due to packaging and dosage uncertainties.

Innovation Solution

Incorporating native starch into a powderous formulation of propandiol mononitrate absorbed onto silica significantly enhances retention, with a weight ratio of starch to formulation ranging from at least 1:1 to 200:1, improving retention by at least 10% to 95%.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If propandiol mononitrate is absorbed onto standard carrier systems (silica), then the active compound can be formulated for feed application, but storage stability deteriorates with significant loss of active compound over time

Engineering Contradiction:

ImproveformulabilityVSAvoidstorage stability

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The patent introduces a second carrier material that acts as an intermediary between the active compound and the first carrier system. This intermediary carrier has specific properties (high surface area, appropriate pore structure, chemical composition) that enable it to strongly adsorb propandiol mononitrate, preventing its loss while maintaining formulability. The dual-carrier system mediates between the need for feed application compatibility and storage stability requirements.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite carrier system combining two different carrier materials with complementary properties. The first carrier (silica) provides basic formulation capabilities, while the second carrier adds enhanced adsorption properties for storage stability. This composite approach allows the system to simultaneously achieve both formulability and reliability that neither carrier could provide alone.

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If propandiol mononitrate is incorporated into feed premixes, then it can be applied to ruminants, but retention of the active compound is significantly reduced

Engineering Contradiction:

Improveapplicability to feedVSAvoidactive compound retention

Core Design Contradiction:

Adaptability or versatilityVSLoss of substance

Solution Approach 1:

The second carrier material serves as a protective intermediary that holds the active compound securely during the feed mixing and storage process. This intermediary prevents the active compound from interacting with other feed components that would cause degradation or loss, while still allowing the formulation to be incorporated into standard feed premixes.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent applies beforehand cushioning by pre-adsorbing the active compound onto the second carrier material before incorporation into the feed premix. This pre-binding protects the active compound from subsequent losses during storage and handling, cushioning against the adverse effects of feed matrix interactions.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

3Measurement precision

If conventional packaging and analysis methods are used to ensure proper dosage, then dosage accuracy can be achieved, but costs and complexity increase significantly

Engineering Contradiction:

Improvedosage accuracyVSAvoidpackaging and analysis requirements

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The dual-carrier system enables self-service by providing inherent stability that eliminates the need for external monitoring and control measures. The active compound remains stable during storage without requiring sophisticated packaging, frequent analysis, or special handling procedures. The system self-regulates through the adsorption properties of the carriers, maintaining dosage accuracy automatically.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The invention replaces expensive, complex monitoring systems with a simple, stable formulation approach. Instead of investing in sophisticated packaging and analysis infrastructure, the solution uses a cost-effective carrier system that provides inherent stability, eliminating the need for ongoing measurement and control expenditures.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The addition of native starch stabilizes the storage of propandiol mononitrate, allowing for consistent dosage and reducing additional costs by maintaining the active compound's effectiveness over time.

Implementation Method 1

propandiol mononitrate absorbed onto silica

Methodology Applied

Scientific EffectAdsorption: Adsorption

Implementation Method 2

the addition of a native starch to a powderous formulation of propandiol mononitrate absorbed onto silica significantly increased the retention of propandiol mononitrate

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentEP3727021B1Storage stable mixtures

Publication Date: 2025.07.23 DSM IP ASSETS BV

AI summary

The present invention relates to improved formulations of propandiol mononitrate and derivatives thereof as well as to the production of such formulations.