Topical 1,3-Propanediol Composition for Skin Microbiome Balance
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Solution Overview
Problem
Maintaining the balance of the skin microbiome by promoting beneficial bacteria while suppressing harmful bacteria is challenging in existing cosmetic compositions.
Innovation Solution
A cosmetic composition containing 1,3-propanediol as an active ingredient, optionally with a boosting ingredient like fructan or yeast extract, formulated in various forms to promote beneficial bacteria growth and inhibit harmful bacteria activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic compositions are used, then general skin care functions are provided, but the balance of skin microbiome cannot be maintained
Solution Approach 1:
The patent changes the chemical parameter by introducing 1,3-propanediol at specific concentrations (0.1-20 wt%) to modulate the skin microbiome. This compound specifically alters the environment to promote beneficial bacteria while suppressing harmful bacteria, thereby maintaining microbiome balance that conventional compositions cannot achieve.
Solution Approach 2:
The patent creates a composite cosmetic composition by combining 1,3-propanediol with boosting ingredients (fructan or yeast extract) at optimized ratios (6:1 to 25:1). This composite approach enhances the microbiome-balancing effect beyond what single ingredients can achieve, resolving the contradiction between reliability and adaptability.
2Reliability
If 1,3-propanediol is added to promote beneficial bacteria, then microbiome balance is improved, but composition complexity increases
Solution Approach 1:
The patent establishes specific concentration parameters for 1,3-propanediol (0.1-20 wt%) and boosting ingredients (0.06-0.25 wt%) to achieve microbiome balance. By defining clear parameter ranges and optimal ratios (6:1 to 25:1), the patent simplifies the formulation process while maintaining reliability, resolving the complexity issue.
3Reliability
If high concentration of 1,3-propanediol is used to suppress harmful bacteria, then microbiome balance is improved, but skin irritation risk increases
Solution Approach 1:
The patent optimizes the concentration parameter of 1,3-propanediol to 0.1-20 wt%, with preferred ranges of 0.2-10 wt% or 1-5 wt%. This parameter optimization ensures sufficient suppression of harmful bacteria while maintaining skin safety, resolving the contradiction between effectiveness and irritation risk.
Solution Approach 2:
The patent introduces boosting ingredients (fructan or yeast extract) as intermediaries that work synergistically with 1,3-propanediol. These intermediaries enhance the antibacterial effect against harmful bacteria while the optimized concentration ratio (6:1 to 25:1) ensures the mixture remains gentle on the skin, reducing irritation risk.
Data Source
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AI summary
The present disclosure relates to a composition for skin external use for maintaining the balance of the skin microbiome, containing 1,3-propanediol as an active ingredient and optionally a boosting ingredient. The composition can be formulated into a cosmetic composition or a pharmaceutical composition for application to the outside of the skin. The composition for skin external use according to the present disclosure can promote the growth of beneficial skin bacteria, suppress the growth of harmful skin bacteria, maintain the balance of the skin microbiome, thereby improve and strengthen the barrier function against external irritants of the skin. It can also help to make skin tissue dense, improve skin texture, and maintain overall skin health.