Propellant-Free Steroid Spray for Skin Permeation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional topical formulations for skin disorders like psoriasis are often irritating, difficult to apply, and require frequent re-application, leading to poor patient compliance and potential 'rebound' effects due to short duration of action, along with environmental and cost concerns related to propellant-based aerosols.
Innovation Solution
Development of propellant-free, non-foaming pharmaceutical topical spray compositions containing steroids like betamethasone, formulated with an aqueous-based emulsion system including an emulsifying agent, polymer, water, and a water-immiscible substance, which are easy to apply and provide sustained release for improved skin permeation and patient comfort.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If propellant-based aerosol formulations are used, then the compositions can be delivered as sprays, but they cause environmental harm and increase cost
Solution Approach 1:
The patent removes propellants from the aerosol formulation entirely, extracting the harmful component while retaining the spray delivery function through alternative mechanisms such as pump-driven or pressure-driven spray systems that do not rely on propellant gases
Solution Approach 2:
The formulation changes the physical state and delivery mechanism parameters by transitioning from propellant-based aerosol spray to propellant-free spray formulation, altering how the composition is delivered while maintaining the beneficial spray application method
2Reliability
If conventional topical formulations are used, then they provide corticosteroid therapy, but they require frequent re-application due to short duration of action
Solution Approach 1:
The formulation incorporates sustained-release mechanisms that maintain continuous therapeutic action of the corticosteroid over an extended period, eliminating the need for frequent re-application while ensuring reliable therapeutic effect throughout the day
Solution Approach 2:
The formulation is designed to pre-release the corticosteroid in a controlled manner over time, providing prolonged therapeutic action from a single application rather than requiring repeated applications to maintain continuous effect
3Reliability
If conventional topical formulations are used, then they deliver corticosteroids to the skin, but they cause skin irritation and poor patient compliance
Solution Approach 1:
The formulation introduces a penetrant enhancer as an intermediary substance that facilitates the delivery of corticosteroid through the skin at lower concentrations, reducing direct irritation while maintaining therapeutic efficacy through improved permeation
Solution Approach 2:
The formulation alters the concentration parameters of the corticosteroid and incorporates soothing agents to change the physical and chemical properties of the composition, thereby reducing irritation while preserving the therapeutic effect
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The propellant-free spray compositions offer improved patient compliance, reduced irritation, and extended duration of action, while being environmentally friendly and cost-effective, with enhanced skin permeation and a soothing effect for psoriasis treatment.
Implementation Method 1
formulated with an aqueous-based emulsion system including an emulsifying agent, polymer, water, and a water-immiscible substance
Implementation Method 2
emulsifying agent
Implementation Method 3
enhanced skin permeation
Implementation Method 4
sustained release for improved skin permeation
Data Source
AI summary
The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.