Propylene Oxide Production via Solvent-Free Epoxidation

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Solution Overview

Problem

Current methods for producing propylene oxide using hydrogen peroxide result in undesirable ring opening byproducts due to the use of methanol and water as solvents, leading to reduced propylene oxide yield.

Innovation Solution

A method involving the oxidation of alpha-methylbenzyl alcohol with air to form hydrogen peroxide and acetophenone, followed by reacting propylene with the resulting mixture in the presence of a titanium support on zeolite catalyst, separating propylene oxide, decomposing hydrogen peroxide, and hydrogenating acetophenone to recycle alpha-methylbenzyl alcohol, thereby minimizing byproducts and eliminating the need for additional solvents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If methanol and water are used as solvents in the epoxidation of propylene with hydrogen peroxide, then the reaction proceeds effectively, but ring opening byproducts are formed and propylene oxide yield is reduced

Engineering Contradiction:
Improvereaction effectivenessVSAvoidring opening byproducts
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent removes methanol and water solvents from the reaction system entirely. The epoxidation reaction is conducted in a solvent-free environment using only the reactants (propylene and hydrogen peroxide) and a solid catalyst (TS-1), thereby eliminating the source of ring opening byproducts while maintaining reaction effectiveness

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the physical state parameters of the reaction system by eliminating liquid solvents and conducting the reaction in a gas-liquid-solid phase system. This parameter change prevents the solvent-catalyzed ring opening side reactions while preserving the main epoxidation pathway

Inventive Principle:
Principle #35Parameter changes

2Productivity

If hydrogen peroxide is used to epoxidize propylene, then propylene oxide is produced, but co-products and ring opening byproducts reduce the overall yield

Engineering Contradiction:
Improvepropylene oxide productionVSAvoidpropylene oxide yield
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The patent converts the harmful effect of hydrogen peroxide decomposition and side reactions into a benefit by using a solid TS-1 catalyst that selectively promotes the epoxidation pathway. The catalyst structure confines the reaction, directing hydrogen peroxide toward epoxide formation rather than decomposition or ring opening, thereby turning potential waste into useful product

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The TS-1 catalyst acts as an intermediary that mediates between hydrogen peroxide and propylene. It activates hydrogen peroxide in a controlled manner and transfers the oxidizing capability to propylene through a selective mechanism, preventing direct uncontrolled reaction and minimizing byproduct formation

Inventive Principle:
Principle #24Intermediary (Mediator)

3Stability of the object's composition

If water is used as a cosolvent in the epoxidation reaction, then the reaction mixture is stable, but propylene glycol byproduct is formed

Engineering Contradiction:
Improvereaction mixture stabilityVSAvoidpropylene glycol byproduct
Core Design Contradiction:
Stability of the object's compositionVSObject-generated harmful factors

Solution Approach 1:

The patent completely removes water from the reaction system. Stability of the reaction mixture is achieved through the solid catalyst structure and controlled gas-liquid contact rather than aqueous solution chemistry, eliminating water-catalyzed ring opening while maintaining operational stability

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This process effectively reduces the formation of co-products and ring opening byproducts, enhancing the yield of propylene oxide and allowing for its production without the use of methanol, thus improving the efficiency of the propylene oxide production process.

Implementation Method 1

oxidizing alpha-methylbenzyl alcohol with air to form a first reaction mixture comprising hydrogen peroxide and acetophenone

Methodology Applied
Scientific EffectOxidation: Oxidation

Implementation Method 2

reacting propylene with the first reaction mixture in the presence of a catalyst to form a second reaction mixture comprising propylene oxide

Methodology Applied
Scientific EffectCatalysis: Catalysis

Implementation Method 3

epoxidation of propylene with hydrogen peroxide in methanol solution using titanium silicate catalysts (TS1)

Methodology Applied
Scientific EffectEpoxidation:

Implementation Method 4

heating the third reaction mixture to decompose hydrogen peroxide, whereby a fourth reaction mixture is formed

Methodology Applied
Scientific EffectDecomposition: Decomposition (biological)

Implementation Method 5

hydrogenating the acetophenone in the fourth reaction mixture with hydrogen to form a fifth reaction mixture comprising alpha-methylbenzyl alcohol

Methodology Applied
Scientific EffectHydrogenation: Hydrogenation

Implementation Method 6

separating the propylene oxide from the second reaction mixture to form a third reaction mixture

Methodology Applied
Scientific EffectDistillation: Distillation

Data Source

PatentEP3283469B1Process for forming propylene oxide from oxidation of methyl benzyl alcohol
Publication Date: 2019.12.11 LYONDELL CHEMICAL TECHNOLOGY LP
  • EP3283469B1 patent drawingFigure 1
  • EP3283469B1 patent drawingFigure 2
  • EP3283469B1 patent drawingFigure 3

AI summary

The present disclosure relates to a method of preparing propylene oxide comprising the steps: (a) oxidizing alpha-methylbenzyl alcohol with air to form a first reaction mixture comprising hydrogen peroxide and acetophenone; (b) reacting propylene with the first reaction mixture in the presence of a catalyst to form a second reaction mixture comprising propylene oxide; (c) separating the propylene oxide from the second reaction mixture to form a third reaction mixture; (d) heating the third reaction mixture to decompose hydrogen peroxide, whereby a fourth reaction mixture is formed; (e) hydrogenating the acetophenone in the fourth reaction mixture with hydrogen to form a fifth reaction mixture comprising alpha-methylbenzyl alcohol; and (f) separating alpha-methylbenzyl alcohol from the fifth reaction mixture and returning the methyl benzyl alcohol to step (a).