Vascular Prosthesis Porous Wall Microparticle Inhibitors
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Solution Overview
Problem
Vascular prostheses made of synthetic materials often suffer from compliance mismatch and thrombogenicity, leading to early occlusion due to the difference in modulus of elasticity and material properties compared to natural vessels, resulting in lower patency rates, especially in small-lumen regions.
Innovation Solution
A vascular prosthesis with a porous synthetic polymer wall containing microparticles embedded with immobilized blood coagulation inhibitors, such as serine protease inhibitors and antithrombins, to reduce thrombus formation by minimizing blood component adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If textile vascular prostheses are used, then structural support is provided, but thrombogenicity increases due to high structural thrombogenicity
Solution Approach 1:
The prosthesis applies different surface qualities to different regions: the inner surface is made smooth and closed to reduce thrombogenicity, while the outer surface maintains a textile structure for structural support. This local differentiation resolves the contradiction between strength and thrombogenicity.
Solution Approach 2:
A polysiloxane coating layer is introduced as an intermediary between the textile structure and the blood-contacting surface. This coating layer provides the smooth, non-thrombogenic surface while allowing the underlying textile structure to provide mechanical strength.
2Adaptability or versatility
If polyurethane vascular prostheses are used, then elasticity and compliance are improved, but thrombogenicity remains an issue
Solution Approach 1:
The polyurethane material provides elasticity and compliance throughout the prosthesis, while the inner surface is specifically treated with a smooth, closed structure and polysiloxane coating to reduce thrombogenicity. This local quality differentiation resolves the contradiction between adaptability and harmful factors.
3Object-affected harmful factors
If inner wall surfaces are made smooth and closed, then adhesion of blood components is reduced, but structural thrombogenicity increases
Solution Approach 1:
The prosthesis differentiates between inner and outer surface properties: the inner surface is made smooth and closed to reduce blood component adhesion, while the outer surface maintains a textile structure for structural strength. This resolves the contradiction between reducing adhesion and maintaining structural integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The immobilization of blood coagulation inhibitors on microparticles within the prosthesis wall significantly reduces thrombosis risk, enhancing the antithrombogenic properties and improving patency rates, particularly in small-lumen vascular replacements.
Implementation Method 1
The blood coagulation inhibitors are preferably immobilized on the surfaces of the microparticles via so-called linkers (spacer molecules). As a rule, the linkers are not bound covalently, preferably adsorptively, to the microparticles.
Implementation Method 2
The immobilization of the linker-inhibitor conjugates described in this section on the microparticle surfaces is preferably based on adsorptive, in particular electrostatic, interactions between the linkers and the microparticle surfaces.
Implementation Method 3
a vascular prosthesis with a porous wall made of synthetic polymer
Data Source
AI summary
The present invention relates to a vascular prosthesis with a porous wall made of synthetic material, wherein the wall is impregnated with microparticles on the surfaces of which blood coagulation inhibitors are immobilized.