Delayed-Release Protease Coating for Bleach-Compatible Detergents

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Solution Overview

Problem

Bleaching agents and enzymes in dishwashing detergents interfere with each other's activity and performance, leading to suboptimal dishwashing results, and existing delayed dosing methods are not universally effective across enzyme variants.

Innovation Solution

A detergent composition with protease enzymes coated in a delayed release coating comprising hydrophobic species, such as fatty acids and esters, ensures minimal interference with bleaching agents by controlled enzyme release.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If bleaching agents and enzymes are both included in detergent composition, then comprehensive cleaning performance is improved, but their mutual interference reduces activity and effectiveness

Engineering Contradiction:
Improvecleaning performanceVSAvoidmutual interference between actives
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The enzyme is separated from the bulk detergent composition by encapsulating it within a delayed release coating, creating a distinct compartment that prevents direct contact and interference with bleaching agents until the coating dissolves at the appropriate time

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The enzyme is pre-coated with delayed release material before detergent formulation, establishing protective barriers in advance that prevent interference during storage and wash cycle initiation, allowing the enzyme to remain inactive and protected until needed

Inventive Principle:
Principle #10Preliminary action

2Object-generated harmful factors

If delayed release coating is applied to protease enzyme, then interference with bleaching agents is minimized, but enzyme distribution and release timing must be precisely controlled

Engineering Contradiction:
Improveinterference with bleaching agentsVSAvoidenzyme release timing control
Core Design Contradiction:
Object-generated harmful factorsVSManufacturing precision

Solution Approach 1:

The coating composition parameters are optimized to achieve desired release characteristics, including using specific ratios of water-soluble polymers, waxes, and other delayed release materials to control dissolution rate and timing

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The delayed release coating is formulated as a composite material system combining multiple components (water-soluble polymers, waxes, oils, fats) that work together to provide controlled release properties, allowing precise tuning of release timing and rate

Inventive Principle:
Principle #40Composite materials

3Reliability

If enzyme coating is optimized for one enzyme variant, then performance with that variant is improved, but efficacy decreases with different enzyme variants

Engineering Contradiction:
Improveenzyme performanceVSAvoidcompatibility with enzyme variants
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The delayed release coating formulation is designed to be universally compatible with multiple protease enzyme variants by using non-specific binding materials and neutral coating components that do not interact preferentially with any particular enzyme structure

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The coating materials are selected to provide uniform properties across different enzyme variants, using homogeneous polymer matrices and consistent coating thickness that treat all enzyme molecules equally regardless of their specific amino acid sequences

Inventive Principle:
Principle #33Homogeneity

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides excellent dishwashing performance, consumer benefits, and cost-effective, simple manufacturing, while maintaining enzyme activity and stability.

Implementation Method 1

a delayed release coating composition comprising at least one hydrophobic species

Methodology Applied
Scientific EffectHydrophobic interaction: Hydrophobe

Data Source

PatentUS20250354091A1Detergent compositions comprising a protease enzyme coated with a delayed release coating
Publication Date: 2025.11.20 RECKITT BENCKISER FINISH BV
  • US20250354091A1 patent drawing
  • US20250354091A1 patent drawing
  • US20250354091A1 patent drawing

AI summary

The invention is related to a detergent composition comprising at least one protease enzyme having at least 95% identity with SEQ ID NO:1, wherein the or each protease enzyme is coated with a delayed release coating composition comprising at least one hydrophobic species.