Protected Iridoid Derivatives for Stable Tanning
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Solution Overview
Problem
Existing tanning methods using aglycone forms of iridoids or seco-iridoids face limitations due to high reactivity, leading to stability, storability, and toxicity issues, and require expensive enzymatic hydrolysis for activation.
Innovation Solution
The use of protected iridoid or seco-iridoid derivatives, where the dihydropyranyloxy moiety is protected with an acyclic acetal group, which can be easily removed under acidic conditions to release the active aglycone form for tanning processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If aglycone forms of iridoids or seco-iridoids are used as tanning agents, then tanning effectiveness is improved, but stability and storability deteriorate due to high reactivity
Solution Approach 1:
The patent applies preliminary protection by introducing an acyclic acetal group to the dihydropyranyloxy moiety of iridoid or seco-iridoid compounds before tanning. This preliminary action creates a stable protected derivative that can be stored and handled safely, then activated in situ during the tanning process to provide the desired tanning effectiveness without the stability issues of the free aglycone form.
Solution Approach 2:
The protected iridoid or seco-iridoid derivative acts as an intermediary form between the stable glycoside and the reactive aglycone. This intermediary compound combines the stability of protected forms with the ability to release the active aglycone form during tanning, resolving the contradiction between stability and reactivity.
2Reliability
If aglycone forms of iridoids or seco-iridoids are used as tanning agents, then tanning effectiveness is improved, but toxicity increases
Solution Approach 1:
The patent applies preliminary protection by introducing an acyclic acetal group to the dihydropyranyloxy moiety of iridoid or seco-iridoid compounds before tanning. This preliminary action creates a stable protected derivative that can be stored and handled safely, then activated in situ during the tanning process to provide the desired tanning effectiveness without the stability issues of the free aglycone form.
Solution Approach 2:
The protected iridoid or seco-iridoid derivative acts as an intermediary form between the stable glycoside and the reactive aglycone. This intermediary compound combines the stability of protected forms with the ability to release the active aglycone form during tanning, resolving the contradiction between stability and reactivity.
3Stability of the object's composition
If glycoside forms of iridoids or seco-iridoids are used, then stability and storability are improved, but activation requires expensive enzymatic hydrolysis
Solution Approach 1:
The protected iridoid or seco-iridoid derivative acts as an intermediary form between the stable glycoside and the reactive aglycone. This intermediary compound combines the stability of protected forms with the ability to release the active aglycone form during tanning, resolving the contradiction between stability and reactivity.
Solution Approach 2:
The patent changes the chemical parameter of the protecting group from a glycoside to an acyclic acetal derivative. This parameter change allows the compound to be activated under mild acidic conditions rather than requiring expensive enzymatic hydrolysis, while maintaining the stability benefits of protected forms.
4Stability of the object's composition
If glycoside forms of iridoids or seco-iridoids are used, then stability and storability are improved, but activation under mild conditions is difficult
Solution Approach 1:
The protected iridoid or seco-iridoid derivative acts as an intermediary form between the stable glycoside and the reactive aglycone. This intermediary compound combines the stability of protected forms with the ability to release the active aglycone form during tanning, resolving the contradiction between stability and reactivity.
Solution Approach 2:
The patent changes the chemical parameter of the protecting group from a glycoside to an acyclic acetal derivative. This parameter change allows the compound to be activated under mild acidic conditions rather than requiring expensive enzymatic hydrolysis, while maintaining the stability benefits of protected forms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides stable, less toxic tanning agents that can be easily activated under mild conditions, enhancing the efficiency and quality of the tanning process while reducing costs.
Implementation Method 1
This acetal protecting group can be easily removed before and/or during a tanning process, typically using acidic conditions, thereby releasing the active aglycone form.
Implementation Method 2
The effectiveness of tanning is usually reflected by its ability to stabilize collagen, namely to limit collagen denaturation and impart good resistance to enzymatic hydrolysis.
Data Source
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AI summary
The present invention relates to the field of tanning. More particularly, the present invention relates to particular iridoid or seco-iridoid derivatives, and their use in a tanning process. It also relates to a process for cross-linking collagen using such derivatives.