Protein-Bound Cannabis Compositions for Dosing Precision
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Smoking medical Cannabis for medicinal use lacks control over proper dosing of active cannabinoids due to varying concentrations in different parts of the plant and from plant to plant, and it also exposes patients to negative impacts of carcinogens in Cannabis smoke.
Innovation Solution
Development of novel compositions comprising a Cannabis component (cannabinoid, flavonoid, or terpenoid) non-covalently bound to a protein (whey or plant protein), which are water-dispersible, enhancing bioavailability, gastrointestinal absorption, and extending the half-life compared to traditional compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If Cannabis plant matter is smoked for medicinal use, then patients can receive therapeutic effects of cannabinoids, but patients lack control over proper dosing due to varying concentrations in different parts of the plant and from plant to plant
Solution Approach 1:
The patent extracts and isolates specific cannabinoids from the Cannabis plant matter, separating them from the variable plant matrix. This extraction process allows for precise measurement and control of cannabinoid dosing, eliminating the variability inherent in whole plant matter while maintaining therapeutic effects.
Solution Approach 2:
The patent changes the physical and chemical parameters of cannabinoid delivery by using standardized extracts with controlled concentrations. This allows for precise dosing parameters to be established and maintained, unlike variable plant matter where concentration varies by location and plant.
2Reliability
If Cannabis plant matter is smoked for medicinal use, then patients can receive therapeutic effects of cannabinoids, but patients are exposed to negative impacts of carcinogens in Cannabis smoke
Solution Approach 1:
The patent extracts only the therapeutic cannabinoid components from the Cannabis plant matter, separating them from harmful constituents including carcinogens found in smoke. This selective extraction delivers reliable therapeutic effects while eliminating carcinogen exposure associated with combustion.
Solution Approach 2:
The patent converts the complex mixture of plant constituents into a purified therapeutic agent. By processing the raw plant material through extraction and purification, the harmful aspects are eliminated while the beneficial therapeutic properties are concentrated and standardized.
3Reliability
If traditional Cannabis compositions are used, then patients receive therapeutic effects, but the compositions have limited bioavailability and shorter half-life
Solution Approach 1:
The patent creates composite formulations combining purified cannabinoids with specific carriers or delivery systems. These composite materials enhance bioavailability and extend half-life by controlling release kinetics and improving absorption, while maintaining the core therapeutic cannabinoid components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions provide enhanced pharmacokinetic profiles with increased bioavailability, uniform dispersion, and extended half-life, while also masking the taste of cannabinoids, thus improving the efficacy and convenience of Cannabis-based medicinal treatments.
Implementation Method 1
a Cannabis component selected from the group consisting of: a cannabinoid, a flavonoid and a terpenoid; and a protein, selected from the group consisting of whey and a plant protein, wherein the Cannabis component is non-covalently bound to the protein
Data Source
AI summary
Described herein are novel compositions comprising a Cannabis component selected from the group consisting of: a cannabinoid, a flavonoid and a terpenoid; and a protein, selected from the group consisting of whey and a plant protein. According to an embodiment, the Cannabis component is non-covalently bound to the whey or to the plant protein. The plant protein may be selected from the group consisting of: soy protein, pea protein, rice protein, hemp protein, and hops protein or other plant derived protein.