Automated Protein Data Filtration for Drug Development

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Solution Overview

Problem

The dynamic and scattered nature of biomedical data related to protein impacts on diseases makes it difficult to determine the exact relationship between proteins and diseases, hindering efficient drug development.

Innovation Solution

A system comprising a protein data extraction module, a protein data filtration module, and a final expression level calculator, which parses and filters data from public databases to calculate the curable action value of target proteins, aiding in drug development.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manual laboratory and computational techniques are used to determine target protein expression, then accurate protein impact information can be obtained, but the process becomes cumbersome and time-consuming

Engineering Contradiction:
Improveprotein expression determination accuracyVSAvoiddrug development time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent creates a computational copy of the manual determination process through machine learning models that replicate protein impact analysis. The system uses trained classifiers to automatically analyze biomedical literature and determine protein expression impacts, replacing time-consuming manual laboratory and computational techniques with an automated digital twin of the analysis process.

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The patent replaces manual mechanical processes (laboratory techniques and human computational analysis) with an automated electronic system. The machine learning-based platform substitutes human experts' manual work with algorithmic processing, using electronic data extraction and classification to determine protein impacts without physical laboratory intervention.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Loss of information

If comprehensive biomedical data is collected from public repositories, then complete protein impact information is available, but the scattered and unorganized nature of data makes analysis difficult

Engineering Contradiction:
Improveprotein impact data completenessVSAvoiddata organization complexity
Core Design Contradiction:
Loss of informationVSDevice complexity

Solution Approach 1:

The patent introduces an intermediary processing layer between the scattered biomedical data and the final analysis results. The system uses natural language processing and machine learning classifiers as intermediaries to automatically organize, filter, and structure unorganized biomedical literature data, transforming scattered text into structured protein impact information without manual intervention.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent transforms the state of biomedical data from unorganized text to structured information by changing key parameters. The system applies text extraction, classification, and filtering operations that convert raw literature data into organized protein impact assessments, fundamentally changing the organizational state of the data from chaotic to structured.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If dynamic updates of biomedical data are tracked, then the most current protein-disease relationships are identified, but the constantly changing data corpus requires continuous monitoring and validation

Engineering Contradiction:
Improveprotein-disease relationship accuracyVSAvoiddata monitoring complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent implements a self-updating system that automatically monitors and processes new biomedical data as it becomes available. The machine learning platform continuously self-updates by ingesting new literature, automatically validating and integrating current protein-disease relationships without requiring manual system reconfiguration or expert intervention for each update cycle.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system incorporates feedback mechanisms where the machine learning models continuously learn from new biomedical literature and update their predictions accordingly. The platform uses feedback from newly published research to refine and update protein impact assessments, ensuring current accuracy through automated continuous learning and adaptation.

Inventive Principle:
Principle #23Feedback

Data Source

PatentUS20250046392A1System and method for aiding drug development
Publication Date: 2025.02.06 INNOPLEXUS AG
  • US20250046392A1 patent drawing
  • US20250046392A1 patent drawing
  • US20250046392A1 patent drawing

AI summary

System (100) and method (200) for aiding drug development by determining a curable action value of a target protein are disclosed. The system (100) comprises a protein data extraction module (110), a protein data filtration module (120), and a final expression level calculator (150). The protein data extraction module (110) is configured for parsing and identifying information related to target proteins from a public database. The public database comprises data related to proteins. The protein data filtration module (120) is configured for filtering out irrelevant information from the identified information related to the target proteins. The final expression level calculator (150) is configured for calculating the final expression level of the identified relevant information. The curable action of the target protein is based upon the final expression level. The invention aids in drug development by determining the curable action of the protein in the disease based on biomedical data corpus.