PRP Base Composition Stabilization for Skin Treatment
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Solution Overview
Problem
Current treatments for skin disorders, nail disorders, hair loss, and signs of aging often involve irritating drugs that require long periods to show improvement and can have adverse effects, with limited options for those with sensitive skin or seeking non-invasive solutions.
Innovation Solution
Development of base compositions that include cell nutrients, biological buffers, viscosity modifying agents, and botanical extracts to prolong the life and stability of biologics like platelet-rich plasma (PRP), which are used in topical formulations for cosmetic application to maintain or improve skin tone and reduce damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional drugs like Retin-A, hydroquinone, glycolic acid, or beta hydroxyl acid are used to treat skin disorders, then skin tone and elasticity can be improved, but the treatments cause irritation, sun sensitivity, peeling, dryness, and can worsen acne
Solution Approach 1:
The patent uses biologics (platelet-rich plasma, stem cells, growth factors) as intermediary substances that mediate skin repair and regeneration processes. These biologics act as natural mediators that stimulate the skin's own healing mechanisms rather than directly acting as harsh chemicals, thereby achieving skin improvement without the irritating side effects of traditional drugs
Solution Approach 2:
The patent changes the fundamental parameter of treatment approach from chemical exfoliation and direct intervention (traditional drugs) to biological stimulation and regeneration (biologics). By changing from chemical parameters (acid concentration, penetration depth) to biological parameters (cell viability, growth factor activity), the treatment achieves efficacy without irritation
2Reliability
If traditional skin treatments are used, then some improvement in skin appearance can be achieved, but the treatments take weeks to show improvement
Solution Approach 1:
The patent applies biologics that contain pre-active growth factors, stem cells, and platelet-derived substances that are already prepared and ready to act immediately upon application. This preliminary preparation of biological agents allows them to begin working instantly on skin regeneration, eliminating the weeks-long delay associated with traditional treatments that require repeated application to build cumulative effect
3Reliability
If biologics like platelet-rich plasma are used in topical formulations, then skin treatment effectiveness is improved, but the biologics have limited stability and short shelf life
Solution Approach 1:
The patent employs inert or controlled atmospheric conditions (nitrogen or oxygen atmosphere, controlled temperature storage) to preserve biologic stability in topical formulations. By creating an inert environment that prevents oxidation and degradation, the biologics maintain their activity and viability for extended periods, solving the shelf life limitation
Solution Approach 2:
The patent uses composite formulation systems that combine biologics with stabilizing matrices, carriers, or protective vehicles. These composite materials provide structural support and protective environment for the delicate biologic components, enhancing their stability and extending their usable lifespan in topical applications
Data Source
AI summary
Disclosed herein are compositions, methods, and systems for treating skin damage or signs of aging in a subject including obtaining whole blood from the subject, collecting platelet rich plasma (PRP) from the whole blood, forming a first topical formulation having the PRP, providing the first topical formulation to the subject for application to an area of skin damage on the subject, providing a second topical formulation to the subject having an activator such that when the second topical formulation is applied to the area of skin damage on top of the first formulation, the PRP is activated and growth factors are released into the area of skin damage. Systems and kits useful in performing the methods are also disclosed.