PRP Storage Platform With Circular Agitation to Limit Aggregation
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Solution Overview
Problem
Existing methods for storing platelet-rich plasma (PRP) are limited by its short shelf-life due to platelet aggregation, necessitating improved apparatus and methods for extended storage.
Innovation Solution
An apparatus configured to reversibly receive a PRP container, featuring an agitator that moves the platform in a circular motion at 10-10,000 RPM, along with a retainer to secure the container and a temperature controller to maintain optimal conditions, thereby reducing activation and debris formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If PRP is stored using conventional static storage methods, then the storage apparatus is simple, but the shelf-life is short due to platelet aggregation
Solution Approach 1:
The patent applies the dynamics principle by transitioning from static storage to dynamic agitation. The storage device incorporates an agitator that moves the platform in a circular motion at controlled frequencies (10-10,000 RPM) to continuously mix the PRP, preventing platelet aggregation while extending shelf-life to up to eight days. This dynamic approach maintains platelet suspension without requiring complex additional systems.
Solution Approach 2:
The patent implements periodic action through controlled agitation cycles. The agitator operates at specific frequency ranges (10-10,000 RPM) to periodically redistribute platelets throughout the PRP sample. This periodic mixing action prevents continuous aggregation while avoiding excessive activation, achieving extended storage duration through rhythmical mechanical stimulation.
2Reliability
If PRP is stored without agitation, then the storage system is simple, but platelet aggregation occurs reducing quality
Solution Approach 1:
The device uses controlled dynamic agitation to maintain reliable PRP quality throughout the storage period. The agitator mechanism, operating within specific frequency parameters (10-10,000 RPM), ensures consistent platelet distribution and prevents aggregation-related quality degradation, making the storage system more reliable despite added mechanical complexity.
Solution Approach 2:
The patent applies parameter changes by controlling agitation frequency within specific ranges (10-10,000 RPM) to optimize PRP quality maintenance. By adjusting this physical parameter, the system achieves reliable platelet suspension without excessive activation, balancing quality consistency with manageable device complexity.
3Stability of the object's composition
If PRP is agitated at high speeds continuously, then platelet aggregation is prevented, but platelet activation and debris formation increase
Solution Approach 1:
The patent uses periodic agitation at controlled frequencies (10-10,000 RPM) to maintain platelet suspension stability while minimizing continuous high-speed stress. The rhythmic mixing action redistributes platelets effectively without sustaining activation levels that lead to excessive debris formation, achieving a balance between suspension stability and platelet integrity.
Solution Approach 2:
The system optimizes the agitation frequency parameter within the range of 10-10,000 RPM to achieve effective platelet suspension while minimizing activation. By carefully selecting and controlling this physical parameter, the device maintains stable platelet composition without generating harmful levels of activation or debris.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The apparatus extends the storage life of PRP to up to eight days, ensuring consistent quality for multiple applications by minimizing platelet activation and debris formation.
Implementation Method 1
an agitator configured to move the platform in a circular motion at a frequency of between 10 and 10,000 revolutions per minute (RPM)
Data Source
AI summary
The disclosure provides an apparatus for storing platelet-rich plasma (PRP). The apparatus is configured to reversibly receive a platelet-rich plasma (PRP) container. The apparatus comprises a platform defining at least one recess configured to receive the PRP container therein; and an agitator configured to move the platform, and thereby agitate PRP stored in the PRP container. The agitator is configured to move the platform in a circular motion at a frequency of between 10 and 10,000 revolutions per minute (RPM).