PRP Separator Assembly Sloped Rotor Design
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Solution Overview
Problem
Current methods for preparing platelet-rich plasma (PRP) concentrates for wound healing and hemostasis often result in suboptimal concentrations of platelets and fibrinogen, with existing devices being cumbersome and requiring additional antifibrinolytic agents, and there is a need for a more efficient and sterile process for producing high-concentration PRP in medical settings.
Innovation Solution
A PRP separator assembly with a cylindrical outer wall and inner wall design, incorporating a depth filter and desiccating beads, which separates erythrocytes from plasma and platelets, allowing for the production of PRP concentrates with enhanced platelet and fibrinogen levels without denaturation, using a combination of centrifugation and desiccation to achieve high concentration factors while maintaining sterility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional centrifugation methods are used to prepare PRP, then platelet concentration is increased, but fibrinogen becomes denatured and additional antifibrinolytic agents are required
Solution Approach 1:
The patent changes the physical parameters of centrifugation by using a specially designed rotor with a slope angle of 0.2 to 5 degrees and specific rotational speeds, which modifies the separation dynamics to prevent fibrinogen denaturation while achieving platelet concentration
Solution Approach 2:
The invention introduces a dimensional aspect by using a sloped surface geometry in the rotor design, creating a gradient separation environment that separates platelets from plasma without the harsh conditions that cause fibrinogen denaturation in conventional horizontal centrifugation
2Quantity of substance
If conventional PRP preparation devices are used, then separation can be achieved, but the devices are cumbersome and not suitable for compact medical settings
Solution Approach 1:
The patent employs a nested design where the separation rotor is contained within a compact housing, and the entire assembly can be integrated into portable medical devices, achieving high separation efficiency in a minimized volume
Solution Approach 2:
The rotor design uses thin-walled construction and flexible sealing mechanisms that maintain structural integrity while minimizing overall device volume, enabling compact portable PRP preparation
3Speed
If high-speed centrifugation is used to increase platelet concentration, then separation speed increases, but erythrocytes contaminate the plasma layer
Solution Approach 1:
The patent optimizes the centrifugation speed parameter within a specific range and uses the sloped rotor geometry to create differential separation zones, allowing high-speed centrifugation to be used without erythrocyte contamination by controlling the radial pressure distribution
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables the production of PRP concentrates with significantly elevated platelet and fibrinogen levels, providing effective wound healing and hemostatic properties, while ensuring sterility and reducing the need for antifibrinolytic agents, with a compact and efficient device suitable for medical use.
Implementation Method 1
The separator assembly can be rotated about the outlet tube to separate erythrocytes from the plasma and platelets
Implementation Method 2
The concentrated platelet-rich plasma is then separated from the beads by rotating the concentrating chamber about its central axis at a speed that separates platelet rich plasma concentrate from the beads
Data Source
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AI summary
A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.