Phosphatidylserine Sodium Salt Curcumin Stabilization
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Solution Overview
Problem
Current pharmaceutical formulations of phosphatidylserine (PS) are prone to degradation and oxidation, limiting their stability and bioavailability, especially when combined with curcumin, which has low bioavailability due to its lipophilicity, making it ineffective in treating brain aging and osteoporosis-related disorders.
Innovation Solution
A stable combination of PS sodium salt and curcumin is developed, which stabilizes PS, preventing degradation and enhancing bioavailability, allowing for the formulation of stable pharmaceutical products in various forms, including soft capsules, tablets, and solutions, thereby maintaining pharmacological properties and improving treatment efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If phosphatidylserine is formulated in conventional pharmaceutical forms, then it can be administered for cognitive disorders, but it degrades and oxidizes rapidly, forming harmful degradation products
Solution Approach 1:
Curcumin acts as an intermediary substance that protects phosphatidylserine from degradation and oxidation. The curcumin molecule interferes with the harmful chemical reactions that would otherwise degrade PS, serving as a protective mediator between PS and environmental factors causing degradation.
Solution Approach 2:
The invention creates a composite pharmaceutical formulation combining phosphatidylserine and curcumin in specific ratios (1:4 to 4:1 w/w). This composite material leverages the stabilizing properties of curcumin to protect the labile phosphatidylserine component, resulting in a formulation with enhanced overall stability.
2Reliability
If curcumin is used to stabilize phosphatidylserine, then degradation is prevented, but curcumin has low bioavailability due to lipophilicity
Solution Approach 1:
The invention optimizes the concentration parameters of both curcumin and phosphatidylserine within specific ranges (0.1-10 mg curcumin per mg PS). By adjusting these parameters, the formulation achieves a balance where curcumin provides sufficient stabilization while remaining at concentrations that improve bioavailability through synergistic absorption mechanisms.
3Adaptability or versatility
If phosphatidylserine is administered alone, then cognitive benefits are achieved, but the treatment is ineffective for osteoporosis and osteoarthritis
Solution Approach 1:
The curcumin-phosphatidylserine formulation achieves multi-functionality, treating not only cognitive disorders but also osteoporosis and osteoarthritis. Curcumin contributes anti-inflammatory and bone-protective properties, while phosphatidylserine provides neuronal membrane stabilization, creating a universally applicable therapeutic agent for multiple age-related conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The PS sodium salt/curcumin combination reduces nitric oxide production, inhibits inflammatory cytokines, and promotes neuronal differentiation, demonstrating synergistic effects in treating neurodegenerative disorders and osteoporosis, with improved bioavailability and stability compared to previous formulations.
Implementation Method 1
Curcumin (diferuloylmethane; 1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) is a liposoluble molecule... its anti-inflammatory and antioxidant power is well documented
Data Source
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AI summary
The present invention describes and claims stable pharmaceutical compositions and/or food supplements based on phosphatidylserine (PS) and curcumin, which are consequently devoid of degradation products, for use in the prevention and treatment of disorders associated with brain aging, and in the prevention and treatment of osteoporosis and/or osteoarthritis.