D-psicose Borate Complex Separation via Chromatography
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Solution Overview
Problem
Current methods for producing D-psicose using the enzymatic conversion method with borate face challenges in economic feasibility due to high costs associated with borate removal and recycling, particularly because conventional techniques require alkaline pH adjustments that degrade the product and necessitate additional processes for removing boron, which complicates industrialization.
Innovation Solution
The method involves using simulated moving bed chromatography to separate D-psicose from borate-containing fractions, achieving high purity D-psicose with minimal borate content by employing divalent cations in chromatography and subsequent ion exchange to recycle borate and fructose, thereby optimizing the separation and recycling of raw materials.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional alkaline pH adjustment is used to remove borate, then borate can be removed from the solution, but the color value rapidly declines and psicose content varies due to alkaline polymerization reaction
Solution Approach 1:
The patent changes the pH parameter from alkaline range (9-11) to neutral range (6.5-7.5), preventing alkaline polymerization reactions while maintaining effective borate removal through reverse osmosis filtration. This parameter change resolves the contradiction by eliminating the harmful alkaline conditions that cause color degradation and psicose variation.
Solution Approach 2:
The patent introduces reverse osmosis filtration as an intermediary process between pH adjustment and borate removal. This intermediary technique enables borate removal without requiring harsh alkaline conditions, thus protecting the psicose product from degradation while achieving effective borate separation.
2Manufacturing precision
If alkaline agent is added to adjust pH for borate removal, then borate can be eliminated, but additional process is needed to remove the introduced alkaline agent
Solution Approach 1:
The patent extracts borate from the solution using reverse osmosis filtration without adding alkaline agents that would require subsequent removal steps. This direct extraction approach eliminates the need for additional neutralization processes, simplifying the overall工艺流程.
3Manufacturing precision
If reverse osmotic filtration is performed at alkaline pH to remove borate, then borate removal efficiency increases, but cost for bleaching increases due to rapid decline of color value
Solution Approach 1:
The patent changes the pH parameter from alkaline (9-11) to neutral (6.5-7.5) before reverse osmotic filtration, preventing color degradation while maintaining borate removal efficiency. This parameter optimization resolves the contradiction by achieving effective borate separation without the harmful side effects of alkaline conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach efficiently separates and removes borate from D-psicose, achieving a D-psicose content of 99% or higher with borate levels below 0.5 ppm, enhancing the economic feasibility and scalability of D-psicose production by reducing processing costs and enabling raw material recycling.
Implementation Method 1
a step of putting a composition comprising a D-psicose borate complex into a chromatography comprising divalent cations; and a step of separating the composition comprising the D-psicose borate complex into a D-psicose containing fraction (i) and a borate-containing fraction (ii)
Implementation Method 2
employing divalent cations in chromatography and subsequent ion exchange to recycle borate and fructose
Data Source
AI summary
The present application relates to a method for producing D-psicose, the method comprising the steps of: putting a composition containing a D-psicose borate complex into a chromatography comprising divalent cations; and separating the composition containing the D-psicose borate complex into a D-psicose-containing fraction (i) and a borate-containing fraction (ii).