Psychedelic Titrating Dosing Regimen Kit

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Solution Overview

Problem

Psychedelics like LSD cause side effects such as hallucinations and perceptual disturbances due to activation of the serotonin 5-HT2A receptor, making their administration unsafe without medical supervision, especially when used repeatedly.

Innovation Solution

A titrating dosing regimen is implemented, starting with a sub-perceptual dose and gradually increasing it over time to minimize side effects while achieving a therapeutic dose, using a kit with dosage forms separated by dose and time, and instructions for administration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a full therapeutic dose of psychedelic is administered immediately, then therapeutic benefits are achieved quickly, but side effects such as hallucinations and perceptual disturbances occur

Engineering Contradiction:

Improvespeed of achieving therapeutic benefitVSAvoidhallucinations and perceptual disturbances

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent divides the full therapeutic dose into multiple smaller sub-doses administered over several days. The kit contains separate dosage forms for each day, with Day 1 containing a lower dose and subsequent days containing higher doses, progressively building tolerance while minimizing acute side effects

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent implements preliminary administration of sub-perceptual or low-dose psychedelic on Day 1 before progressing to full therapeutic doses. This preliminary action allows the patient's 5-HT2A receptors to begin down-regulation in advance, reducing the intensity of hallucinogenic effects when higher doses are administered in subsequent days

Inventive Principle:

Principle #10Preliminary action

2Reliability

If medical supervision is provided during psychedelic administration, then patient safety is ensured, but ease of operation and accessibility are reduced

Engineering Contradiction:

Improvepatient safetyVSAvoidaccessibility and convenience

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent enables patients to self-administer psychedelics at home without requiring continuous medical supervision. The pre-packaged titration kit provides clear instructions and pre-measured doses, allowing patients to safely manage their own treatment while reducing healthcare system burden

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent introduces a specially designed titration kit as an intermediary tool between the psychedelic substance and the patient. The kit includes pre-packaged dosage forms with precise amounts, administration instructions, and safety guidelines, mediating the interaction to ensure safe self-administration

Inventive Principle:

Principle #24Intermediary (Mediator)

3Duration of action of stationary object

If repeated administration of psychedelics is performed, then therapeutic benefits are maintained and enhanced, but side effects initially occur until tachyphylaxis develops

Engineering Contradiction:

Improveduration of therapeutic benefitVSAvoidinitial hallucinations and perceptual disturbances

Core Design Contradiction:

Duration of action of stationary objectVSObject-affected harmful factors

Solution Approach 1:

The patent implements a dynamic dosing schedule where the dose amount changes over time. The titration regimen starts with low doses on Day 1 and progressively increases through Day 7, adapting to the patient's developing tolerance and receptor down-regulation state to maintain therapeutic benefit while minimizing side effects at each stage

Inventive Principle:

Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach reduces the occurrence of hallucinations and perceptual disturbances while maintaining the therapeutic benefits of psychedelics, allowing for safer administration and minimizing risks associated with these side effects.

Implementation Method 1

All serotonergic psychedelics including LSD, psilocybin, DMT, and mescaline are nonspecific serotonin agonists including agonist activity at the serotonin 5-HT2A receptor

Methodology Applied

Scientific EffectSerotonin 5-HT2A receptor activation:

Implementation Method 2

blockade of this activity (by administration of a 5-HT2A antagonist, such as ketanserin) can attenuate these psychoactive/hallucinogenic side effects

Methodology Applied

Scientific Effect5-HT2A receptor blockade:

Data Source

PatentUS20230346645A1Method of titrating dose of psychedelics

Publication Date: 2023.11.02 DEFINIUM THERAPEUTICS US INC

AI summary

A method of dosing a psychedelic that avoids the side effects of hallucinations and perceptual disturbances by administering the psychedelic to an individual in a titrating dosing regimen and reducing side effects of hallucinations and perceptual disturbances. A kit for administering a titrating dosing regimen of a psychedelic, including a pharmaceutically effective amount of the psychedelic in dosage forms separated in packaging according to dose and time of administration in a titrating dosing regimen, and instructions for use. A method of treating an individual with psychedelics, by administering the psychedelic to the individual having a condition or disease in a titrating dosing regimen and reducing side effects of hallucinations and perceptual disturbances during treatment.