Pterostilbene for Ovarian Function Preservation

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Solution Overview

Problem

The increasing age gap between suitable pregnancy ages and desired pregnancy ages leads to modern-type infertility due to deteriorated ovarian function, and existing reproductive technologies are unable to effectively address the decline in ovarian function, affecting pregnancy rates in both humans and animals.

Innovation Solution

The use of pterostilbene as an agent to prevent or improve deterioration of ovarian function, either as a pharmaceutical composition or a food/beverage component, which suppresses the reduction of implantation and live offspring rates, reduces abortion rates, and enhances reproductive ability by increasing the quality and quantity of ovulated eggs and fertilization outcomes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If assisted reproductive technology is used to address infertility, then fertilization capability is improved, but ovarian function deterioration cannot be prevented

Engineering Contradiction:

Improvefertilization capabilityVSAvoidovarian function duration

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies preliminary action by administering pterostilbene before ovarian function deterioration occurs, specifically targeting the prevention of age-related egg quality decline and ovarian aging. The compound is given in advance to protect and maintain ovarian reserve, rather than treating infertility after it has developed.

Inventive Principle:

Principle #10Preliminary action

2Productivity

If pterostilbene is administered to prevent ovarian function deterioration, then implantation rate and live offspring rate are improved, but the mechanism requires understanding of mitochondrial and oxidative stress effects

Engineering Contradiction:

Improveimplantation rate and live offspring rateVSAvoidmechanism complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by modulating mitochondrial function and oxidative stress levels through pterostilbene administration. The compound affects biochemical parameters such as mitochondrial membrane potential, ATP production, and reactive oxygen species levels, thereby improving egg quality and reproductive outcomes without requiring complex mechanical interventions.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Pterostilbene effectively increases the implantation and live offspring rates while reducing abortion rates, thereby addressing the deterioration of ovarian function and improving fertility in both humans and animals, as demonstrated by experimental studies on mice.

Implementation Method 1

Pterostilbene is known to have physiological activities such as antioxidant action

Methodology Applied

Scientific EffectAntioxidant action: Oxidation

Implementation Method 2

resveratrol improves the mitochondrial function and fertilization outcome of oocytes

Methodology Applied

Scientific EffectMitochondrial function improvement:

Data Source

PatentEP3517107B1Agent for preventing or ameliorating reduction in ovarian function

Publication Date: 2023.11.01 PARTNERS CO LTD

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AI summary

An object of the present invention is to provide a preparation effective for prevention and/or improvement of deterioration of ovarian function. An agent for preventing or improving deterioration of ovarian function, the agent including pterostilbene, is provided.