Ptger3 Neuron Modulation for Aversive Taste Control
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Solution Overview
Problem
There is a need for identifying modulators for aversive taste tolerance and developing methods and compositions to modulate aversive taste tolerance in subjects, particularly in those with sodium depletion or related health conditions.
Innovation Solution
Inhibiting or stimulating prostaglandin receptor type 3 (Ptger3)-positive neurons in the lamina terminalis to reduce or increase aversive taste tolerance, respectively, by administering Ptger3-inhibitors or activators, such as small molecules, antibodies, or nucleic acids, or using optogenetic or chemogenetic methods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If Ptger3-positive neurons in the lamina terminalis are inhibited, then aversive taste tolerance is reduced, but sodium intake may increase
Solution Approach 1:
The patent applies parameter changes by modulating the activity state of Ptger3-positive neurons in the lamina terminalis. By changing the neural activity parameter (from active to inhibited), the patent reduces aversive taste tolerance and enables controlled sodium intake, transforming the neural state to achieve therapeutic effects in conditions like hypertension and kidney disease
2Object-affected harmful factors
If Ptger3-positive neurons in the lamina terminalis are stimulated, then aversive taste tolerance is increased, but sodium intake may decrease
Solution Approach 1:
The patent applies parameter changes by modulating the activity state of Ptger3-positive neurons in the lamina terminalis. By changing the neural activity parameter (from inactive to stimulated), the patent increases aversive taste tolerance and enables controlled reduction of sodium intake, transforming the neural state to achieve therapeutic effects in conditions like hypertension and kidney disease
3Object-affected harmful factors
If Ptger3-inhibitors or activators are administered, then aversive taste tolerance is modulated, but device complexity increases
Solution Approach 1:
The patent applies the intermediary principle by using Ptger3-inhibitors or activators as mediating substances. These chemical intermediaries bind to Ptger3 receptors on neurons in the lamina terminalis, transferring the modulation signal and enabling controlled changes in aversive taste tolerance without requiring complex direct neural intervention systems
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The proposed method effectively reduces or increases aversive taste tolerance in subjects, allowing for reduced ingestion of sodium and aversive substances or increased tolerance, as assessed by changes in sodium and aversive substance intake.
Implementation Method 1
inhibiting a plurality of prostaglandin receptor type 3 (Ptger3)-positive neurons in the lamina terminalis (LTPtger3-neurons) of the subject, thereby reducing aversive taste tolerance in the subject
Implementation Method 2
using optogenetic or chemogenetic methods
Data Source
AI summary
Disclosed herein include methods and compositions suitable for use in modulation of aversive taste tolerance. In some embodiments, ingestion of sodium and/or aversive substances is reduced. Also disclosed include methods for identifying modulators for aversive taste tolerance.