Bioabsorbable PTMC Intestinal Stent for Tissue Repair
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Solution Overview
Problem
Current intestinal anastomosis stents lack biodegradability, mechanical matching with intestinal tissues, and regulatory functions for tissue repair, leading to complications such as anastomotic fistula and stenosis.
Innovation Solution
A PTMC-based intestinal anastomosis stent made of a bioabsorbable flexible elastomer, synthesized via ring-opening polymerization and electrospinning, with a thickness of 0.05-0.3 mm and loaded with triclosan for antibacterial properties, providing mechanical matching and tissue repair regulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If metal staplers are used for intestinal anastomosis, then the mechanical strength and structural stability are improved, but the biodegradability is lost resulting in permanent retention in the body
Solution Approach 1:
The patent changes the material parameter from metal to bioabsorbable polymer (polyglycolide and polylactide), transforming the stent from permanent to temporarily functional. This parameter change enables the stent to provide mechanical strength during the critical healing period while gradually degrading and being absorbed by the body, eliminating the need for permanent retention or removal surgery.
Solution Approach 2:
The patent employs a disposable, biodegradable stent design where the polyglycolide and polylactide materials serve their mechanical support function temporarily during intestinal healing, then naturally degrade and are eliminated by the body. This short-living object approach replaces permanent metal staplers, avoiding long-term foreign body retention while providing sufficient mechanical strength when needed.
2Duration of action of stationary object
If degradable high molecular material staplers are used, then the biodegradability is improved, but the mechanical matching with wound tissues is insufficient
Solution Approach 1:
The patent uses composite materials consisting of polyglycolide and polylactide in specific ratios (70:30 to 30:70). This composite approach combines the advantages of both materials: polyglycolide provides good biodegradability and flexibility, while polylactide contributes to mechanical strength and stiffness. The composite structure achieves both biodegradability and adequate mechanical matching with wound tissues, resolving the contradiction between these two properties.
Solution Approach 2:
The patent applies different material compositions to different regions or aspects of the stent structure to optimize local properties. By adjusting the polyglycolide-polylactide ratio in different formulations (multiple embodiments with different ratios), the stent achieves optimal mechanical matching at the tissue interface while maintaining overall biodegradability, allowing local quality optimization for specific functional requirements.
3Ease of operation
If conventional staplers are used for anastomosis, then the surgical procedure is simplified, but the regulatory and control functions for tissue repair are lost
Solution Approach 1:
The patent enables the stent to perform self-service functions by incorporating bioactive components that actively regulate tissue repair processes. The stent doesn't merely provide passive mechanical support but actively participates in the healing process through controlled drug release, inflammatory modulation, and tissue regeneration promotion. This self-service capability adds regulatory functions while maintaining ease of surgical implantation.
Solution Approach 2:
The patent transforms the single-function metal stapler into a multi-functional device that simultaneously provides mechanical support, controlled drug delivery, inflammatory regulation, and tissue regeneration promotion. The stent serves multiple purposes: structural reinforcement during healing, localized anti-inflammatory therapy, antimicrobial protection, and stimulation of tissue regrowth, thereby achieving adaptability and versatility without complicating the surgical procedure.
4Strength
If the stent thickness is increased to improve mechanical strength, then the structural stability is improved, but the flexibility and adaptability to intestinal peristalsis deteriorates
Solution Approach 1:
The patent optimizes the thickness parameter of the stent to achieve a balance between mechanical strength and flexibility. By carefully selecting the thickness within a specific range and adjusting the polyglycolide-polylactide ratio, the stent achieves sufficient structural stability to maintain the anastomosis site while retaining enough flexibility to accommodate intestinal peristalsis and movement without causing discomfort or compromising adaptability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stent effectively reduces the occurrence probability of intestinal anastomotic fistula and other complications by matching intestinal elasticity, regulating tissue repair, and providing antibacterial protection, while being easily manufactured and biodegradable.
Implementation Method 1
the PTMC copolymer is a polymer material synthesized by a ring-opening polymerization method of a high-molecular medical material PTMC monomer
Implementation Method 2
The anastomosis stent is prepared by using an electrospinning method
Data Source
AI summary
A PTMC-based intestinal anastomosis stent of a bioabsorbable flexible elastomer and a preparation method therefor. The intestinal anastomosis stent that uses PTMC as a base material is prepared by using an electrospinning method, and an appropriate range suitable for being implanted into the body is screened out according to a degradation rate and a mechanical property. The stent is loaded with TCS having a bactericidal effect, so that the stent has a tissue repair adjustment function, enabling a wound to heal more quickly in a severe multi-bacterial intestinal environment, and for adjusting postoperative tissue healing and functional repair. An in-vivo animal intestinal anastomosis experiment is carried out, thus verifying the practical effects and the feasibility of the method.