PTMC-b-PEG-b-PTMC Stent for Degradable Intestinal Anastomosis
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Solution Overview
Problem
Current intestinal anastomosis stents are non-degradable, lack mechanical matching with tissue, and fail to regulate tissue repair, leading to complications like anastomotic fistula and stenosis, and they are not easily manufactured in various sizes.
Innovation Solution
A bioflexible elastomer intestinal anastomosis stent based on PTMC-b-PEG-b-PTMC copolymer with a plant cellulose tube sleeve, designed for seamless integration and degradability, featuring adjustable dimensions and antibacterial properties to reduce complications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If metal staplers are used for intestinal anastomosis, then anastomosis strength is improved, but biodegradability deteriorates resulting in permanent retention in the body
Solution Approach 1:
The patent changes the material parameters from permanent metal to biodegradable high molecular materials, adjusting the duration of action to match the healing period while maintaining sufficient strength during the critical early phase
Solution Approach 2:
The stent is designed to be temporarily retained and then naturally degraded and excreted by the body after completing its function of supporting anastomosis healing, eliminating the need for permanent retention or secondary removal surgery
2Duration of action of moving object
If degradable high molecular material staplers are used, then biodegradability is improved, but mechanical matching with wound tissue deteriorates
Solution Approach 1:
The patent optimizes the molecular weight, composition ratio, and crosslinking degree of the copolymer to achieve the perfect balance between degradation rate and mechanical strength, ensuring the stent maintains structural integrity while providing mechanical matching with healing tissue
Solution Approach 2:
The patent uses PTMC-b-PEG-b-PTMC triblock copolymer combining hydrophobic PTMC blocks for structural strength and hydrophilic PEG blocks for controlled degradation, creating a composite material system that simultaneously satisfies both mechanical and biodegradability requirements
3Ease of operation
If conventional staplers are used, then anastomosis is achieved, but regulation and control function of tissue repair deteriorates
Solution Approach 1:
The patent incorporates functional factors into the stent material that provide feedback control over the tissue repair process, allowing the stent to actively regulate inflammation, proliferation, and remodeling phases based on the healing progress
Solution Approach 2:
The stent material itself serves multiple functions including structural support, controlled degradation, and active regulation of tissue repair through embedded functional factors, eliminating the need for additional separate regulation mechanisms
4Ease of manufacture
If stents with fixed dimensions are used, then manufacturing is simplified, but adaptability to different individuals deteriorates
Solution Approach 1:
The patent designs the stent with adjustable and adaptable dimensions that can be customized for different patients' anatomical requirements, while maintaining ease of manufacture through modular design and standardized production processes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stent provides effective intestinal content isolation, minimizes tissue damage, and reduces anastomotic fistula and stenosis by degrading within 2-3 weeks, enhancing surgical ease and reducing medical costs.
Implementation Method 1
The copolymer has a degradation time of 2-3 weeks in the body and can be excreted from the body through the intestinal tract
Implementation Method 2
The copolymer has a degradation time of 2-3 weeks in the body
Implementation Method 3
The stent is prepared by electrospinning
Data Source
AI summary
A bioflexible elastomer intestinal anastomosis stent based on a PTMC-b-PEG-b-PTMC copolymer, and a preparation method. Biocompatible degradable polymer medical materials, i.e., PTMC and PEG, are selected, an electrostatic spinning method is used for preparation, the size of an anastomosis tube can be adjusted according to the size of a human lumen, and the anastomosis tube is designed to not only be suitable for an anastomat of the small intestines and large intestines, but also suitable for an anastomotic and pre-supported lumen anastomat of an esophagus, artery, vein, etc. The anastomosis tube prepared has a thin wall and excellent elasticity, and in order to facilitate suturing by a doctor during a clinical surgical operation, the anastomosis tube is innovatively and seamlessly sleeved outside a plant cellulose tube having high hardness.