Puer Tea Extract Composition for Ulcerative Colitis Inflammation

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Solution Overview

Problem

Current treatments for ulcerative colitis, a chronic inflammatory bowel disease, often cause side effects and may lead to drug resistance, necessitating the development of a safer and more effective natural therapeutic agent.

Innovation Solution

A composition containing puer tea extract is developed, which inhibits inflammatory cytokines, reduces oxidative stress, and alleviates symptoms of ulcerative colitis by regulating NF-κB activity and scavenging free radicals, formulated as a food, health functional food, pharmaceutical, or feed composition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional therapeutic agents (aminosalicylate preparations, steroid preparations, immunosuppressants) are used to treat ulcerative colitis, then the disease can be managed, but side effects occur and drug resistance may develop

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidside effects and drug resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent employs natural substances (puer tea extract, green tea extract, oolong tea extract) as temporary, non-persistent therapeutic agents that act through natural mechanisms rather than long-lasting synthetic drugs. These natural extracts provide symptom relief and anti-inflammatory effects without the accumulation of drug resistance or severe side effects associated with conventional long-term pharmaceutical treatments

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent introduces natural extracts as intermediary substances that mediate between the patient's immune system and the disease process. These extracts contain bioactive compounds (polyphenols, flavonoids, caffeine) that modulate inflammatory pathways and immune responses, serving as a bridge therapy that reduces reliance on aggressive conventional medications

Inventive Principle:

Principle #24Intermediary (Mediator)

2Duration of action of stationary object

If long-term drug administration is used to manage ulcerative colitis, then disease control is maintained, but various side effects occur ranging from common to severe

Engineering Contradiction:

Improvelong-term disease controlVSAvoidside effects including nausea, vomiting, indigestion, loss of appetite, headache, skin rash, fever, pancreatitis, hepatitis, hemolytic anemia, and bone marrow suppression

Core Design Contradiction:

Duration of action of stationary objectVSObject-affected harmful factors

Solution Approach 1:

The patent leverages the body's own natural defense mechanisms and metabolic pathways to achieve disease control. The natural tea extracts utilize existing physiological processes (digestion, absorption, metabolism) and work with the body's immune system rather than forcing external chemical interventions, thereby avoiding the accumulation of toxic side effects over time

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent changes the chemical and physiological parameters of treatment by using natural extracts with different molecular structures and mechanisms of action compared to conventional drugs. These extracts contain polyphenols, flavonoids, and other bioactive compounds that modulate inflammatory markers, oxidative stress, and immune cell function through natural biochemical pathways, providing a safer profile for long-term use

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The puer tea extract effectively reduces weight loss, diarrhea, and rectal bleeding in ulcerative colitis models, inhibits inflammatory cytokines, and demonstrates antioxidant properties, providing a safer and more effective treatment option.

Implementation Method 1

scavenging free radicals

Methodology Applied

Scientific EffectFree radical scavenging: Absorption (physical)

Implementation Method 2

demonstrates antioxidant properties

Methodology Applied

Scientific EffectAntioxidant activity: Oxidation

Implementation Method 3

inhibits inflammatory cytokines, and demonstrates antioxidant properties, providing a safer and more effective treatment option

Methodology Applied

Scientific EffectTranscription factor inhibition:

Data Source

PatentUS12447187B2Composition for preventing and treating inflammatory bowel disease including puer tea extract

Publication Date: 2025.10.21 CHONG KYONG WON

AI summary

Provided is a method for preventing and alleviating inflammatory bowel disease by administering a composition including puer tea extract as an active ingredient to a subject in need thereof. Puer tea extract of the present disclosure showed an effect of improving damaged colonic tissue in a mouse model of acute ulcerative colitis induced by dextran sulfate sodium (DSS), and showed an inhibitory effect on clinical symptoms of the disease activity index (DAT) of weight loss, diarrhea, and rectal bleeding. In addition, puer tea extract inhibited the expression of inflammatory cytokines TNF-α and IL-6 in the colonic tissue and inhibited the inflammatory response through inhibition of the activity of NF-κB, an anti-inflammatory mechanism. In addition, the DPPH free radical and ABTS free radical scavenging ability increased proportionally as the concentration of puer tea extract increased at the cellular level, and COX-2 expression was inhibited in LPS-activated macrophages.