Pulmonary Ligament Tissue Fixation for Stent Scaffolds
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Solution Overview
Problem
Current biological tissue scaffolds, such as small intestinal submucosa, lose elasticity and biological advantages after fixation, making them less effective for medical applications.
Innovation Solution
Processing pulmonary ligament tissue by acquiring, selecting, and fixing samples using a fixative like glutaraldehyde, maintaining the tissue's elasticity and biological properties for use in medical devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If small intestinal submucosa tissue is fixed, then the tissue structure is stabilized, but the tissue loses elasticity and biological advantages
Solution Approach 1:
The patent changes the chemical parameters of fixation by using glutaraldehyde at controlled concentrations (0.25%-2%) and specific pH conditions (pH 7.2-7.4), along with controlled fixation time and temperature, to achieve a balance between structural stabilization and elasticity preservation that differs from conventional fixation approaches
Solution Approach 2:
The patent creates a composite structure by combining fixed pulmonary ligament tissue with a metallic stent framework, where the tissue provides biological functionality and elasticity while the metal framework provides structural support, achieving both stability and elasticity requirements
2Duration of action of stationary object
If tissue is fixed using conventional methods, then the tissue is preserved, but biological advantages are lost
Solution Approach 1:
The patent optimizes fixation parameters including using glutaraldehyde concentrations between 0.25%-2%, maintaining pH 7.2-7.4, and controlling fixation duration to preserve biological functionality while achieving adequate tissue preservation, representing a refined parameter set compared to conventional fixation
Solution Approach 2:
The patent uses buffering agents (phosphate buffer, HEPES buffer) as intermediaries during fixation to maintain optimal pH conditions and protect biological structures from excessive cross-linking, thereby preserving biological advantages while achieving preservation
3Strength
If pulmonary ligament tissue is fixed, then elasticity is maintained, but processing complexity increases
Solution Approach 1:
The patent performs preliminary actions by pre-processing the pulmonary ligament tissue through cleaning, trimming, and initial fixation before stent assembly, which simplifies subsequent assembly steps and reduces overall processing complexity while maintaining elasticity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The processed pulmonary ligament tissue retains its elasticity and biological advantages, making it suitable for various medical applications, including valves and tissue replacements, with improved durability and stretchability.
Implementation Method 1
fixing the sample of pulmonary ligament tissue using a fixative, resulting in a fixed sample
Data Source
AI summary
Methods and uses of biological tissues for various stent and other medical applications. In an exemplary embodiment of a method of processing a tissue of the present disclosure, the method comprises the steps of acquiring a mammalian tissue comprising at least a portion of a pulmonary region tissue, selecting a sample of pulmonary region tissue from the at least a portion of a pulmonary region tissue, and fixing the sample of pulmonary region tissue using a fixative, resulting in a fixed sample. In at least one embodiment, the step of selecting a sample of pulmonary region tissue comprises selecting a sample of pulmonary ligament tissue from the mammalian tissue.