Pulmonary Artery Stent With Isolation Membrane
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Solution Overview
Problem
Traditional vascular stents for treating pulmonary artery stenosis fail to accommodate blood vessel growth, lead to in-stent restenosis due to intimal hyperplasia, and are prone to displacement under high blood flow velocities and pressures.
Innovation Solution
A pulmonary artery stent designed with a metal stent capable of circumferential expansion, wrapped with an isolation membrane to prevent irritation and intimal hyperplasia, and featuring a drug delivery system for targeted thrombolysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a traditional vascular stent is used to treat pulmonary artery stenosis, then the stent can provide initial structural support, but it cannot accommodate blood vessel growth over time and leads to in-stent restenosis
Solution Approach 1:
The stent structure incorporates expandable elements that can dynamically adjust to accommodate blood vessel growth. The stent includes compression members connected by connectors that allow the stent to expand radially as the blood vessel grows, maintaining adaptability while providing continuous support to prevent restenosis
Solution Approach 2:
The stent is divided into multiple modular segments including compression members and connectors. This segmentation allows independent adjustment of each segment to accommodate varying growth rates differentially across the stent length, improving adaptability while maintaining overall structural reliability
2Strength
If a traditional vascular stent is implanted in the pulmonary artery, then it provides structural support, but it causes local irritation leading to intimal hyperplasia and in-stent restenosis
Solution Approach 1:
A thin-film coating is applied to the stent surface to create a biocompatible barrier between the metal stent structure and the blood vessel wall. This flexible film reduces local irritation and prevents intimal hyperplasia while allowing the stent to maintain its structural support function
Solution Approach 2:
The stent combines metal structural elements with biocompatible material coatings to create a composite structure. The metal provides necessary strength and support, while the coating material reduces biological rejection and prevents hyperplastic response
3Strength
If a traditional vascular stent is implanted in the pulmonary artery, then it provides support, but it is easily displaced under high blood flow velocity and pressure
Solution Approach 1:
The stent is divided into multiple segments with connectors that can differentially expand. This segmentation allows the stent to conform to the vessel wall more effectively at different locations, improving anchoring and stability under high flow conditions while maintaining support capability
Solution Approach 2:
Different portions of the stent have different expansion characteristics and structural properties. The connectors and compression members are designed with varying stiffness and expansion ratios to optimize local anchoring in high-flow regions while maintaining overall support function
4Quantity of substance
If traditional catheter thrombolysis is used to treat pulmonary embolism, then it can dissolve clots, but it requires long catheter placement time and large doses of thrombolytic agent resulting in low efficiency and high wastage
Solution Approach 1:
The stent incorporates drug reservoirs and delivery channels that enable it to autonomously deliver thrombolytic agents directly to the thrombus site. The stent structure itself serves as the drug delivery system, eliminating the need for external catheter placement and achieving targeted therapy with reduced agent wastage
Solution Approach 2:
The thrombolytic agent is pre-loaded into the stent structure before implantation. Upon deployment, the drug is immediately delivered to the thrombus site, eliminating the need for prolonged catheter placement and large-volume systemic administration, thereby improving efficiency and reducing wastage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stent provides continuous support to expanding blood vessels, prevents in-stent restenosis, and enhances thrombolysis efficiency by delivering drugs directly to the thrombus, reducing agent wastage and treatment time.
Implementation Method 1
an isolation membrane wrapping the metal stent to isolate the metal stent from an external environment
Implementation Method 2
featuring a drug delivery system for targeted thrombolysis
Data Source
AI summary
The present disclosure provides a pulmonary artery stent. The pulmonary artery stent includes: a metal stent capable of circumferential expansion; and an isolation membrane wrapping the metal stent to isolate the metal stent from an external environment, and the isolation membrane having a circumferential tensile strength less than an axial tensile strength. The embodiments of the present disclosure can not only expand the diameter of the stent according to a change in the diameter of a blood vessel to meet a support performance requirement after the blood vessel enlarges but also isolate the metal portion of the stent from a vascular environment, thus effectively solving a problem of in-stent restenosis.