Pulsating Vein Occlusion Device for Neoangiogenesis
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Solution Overview
Problem
Existing methods for intermittent occlusion of veins, such as the coronary sinus, fail to maintain a prolonged increase in pressure necessary for stimulating neoangiogenesis, as occlusion must be intermittently released due to plateau pressure maxima, limiting the effectiveness of pressure-induced vascular growth factor release.
Innovation Solution
A device applying pulsating pressure during occlusion, using an oscillating body to generate pressure waves of 50-250 per minute, synchronized with heart signals, to enhance endothelial stimulation and neoangiogenesis, with the oscillating body coupled to the occlusion device and secured by a stent-like cage to prevent vessel wall collision.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If intermittent occlusion is performed using conventional methods, then the vein can be occluded to enable retrograde perfusion, but the pressure increase cannot be maintained prolonged due to plateau pressure maxima requiring intermittent release
Solution Approach 1:
The patent applies periodic action by introducing an oscillating body that generates pressure waves at frequencies of 50-250 per minute during the occlusion period. This periodic pressure application maintains elevated pressure levels throughout the occlusion duration, enabling prolonged stimulation of endothelial growth factors and neoangiogenesis without the need to release the occlusion due to plateau pressure maxima.
2Object-affected harmful factors
If the occlusion is released intermittently to avoid plateau pressure maxima, then the vein can be protected from excessive pressure, but the pressure-induced vascular growth factor release is limited
Solution Approach 1:
The patent employs mechanical vibration through an oscillating body that generates pressure waves at frequencies of 50-250 per minute. This vibration mechanism allows the system to maintain elevated pressure levels without causing harmful excessive pressure buildup, as the oscillating pressure waves distribute the mechanical stress dynamically, thereby promoting vascular growth factor release and neoangiogenesis.
Solution Approach 2:
The patent applies parameter changes by modulating the pressure application through oscillating pressure waves with frequencies of 50-250 per minute. This dynamic parameter variation allows the system to maintain pressure within beneficial ranges that stimulate vascular growth factors while avoiding harmful excessive pressure levels, thus optimizing both safety and productivity.
3Duration of action of moving object
If an oscillating body is introduced to generate pressure waves, then prolonged pressure increase can be achieved, but the device complexity increases
Solution Approach 1:
The patent applies the nested doll principle by placing the oscillating body within the occlusion device structure. The oscillating body is positioned inside the catheter or occlusion apparatus, allowing it to generate pressure waves through the existing occlusion mechanism without requiring a completely separate complex system. This nesting approach extends the duration of pressure increase while minimizing the increase in overall device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The pulsating pressure application significantly enhances the production of vascular endothelial growth factors, promoting neoangiogenesis by maintaining higher peak pressure values and efficient pressure wave generation, improving tissue nourishment and waste removal in ischemic areas.
Implementation Method 1
A device applying pulsating pressure during occlusion, using an oscillating body to generate pressure waves of 50-250 per minute
Implementation Method 2
secured by a stent-like cage to prevent vessel wall collision
Data Source
Figure 1
Figure 2
AI summary
In a method for the intermittent occlusion of a vein draining the organ system, wherein the vein is occluded by means of an occlusion device, the fluid pressure in the occluded vein is continuously measured and stored, the course of the fluid pressure is determined as a function of time, and the occlusion of the vein is triggered and/or released as a function of at least one parameter derived from the measured pressure values, pressure is applied during the occlusion in a pulsing manner. The device for the intermittent occlusion of the vein comprises an occlusion device (5), a pressure measuring device (7) for the continuous measuring of the fluid pressure in the occluded vein, and a repository for the course of the fluid pressure as a function of the time, is characterized in that means (8) are provided for applying pressure in the occluded vein in a pulsing manner.