Pulse Ablation Catheter for Pulmonary Arterial Hypertension
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for pulmonary arterial hypertension, such as radiofrequency and cryoablation, lack specificity and safety, particularly in avoiding damage to adjacent tissues like the coronary artery and phrenic nerve, and there is a need for a more effective and faster ablation method.
Innovation Solution
A pulse ablation catheter with a movable outer sheath tube, ablation catheter, functional guide core, and pulse ablation part, featuring strip-shaped arches with pulse electrode sheets powered by an energy platform, allowing for controllable frequency and shape of ablation to target pulmonary arterial tissues while minimizing damage to surrounding tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If radiofrequency ablation or cryoablation is used to treat pulmonary arterial hypertension, then ablation of pulmonary artery tissues can be achieved, but adjacent tissues such as coronary artery and phrenic nerve may be damaged due to lack of selectivity
Solution Approach 1:
The patent applies local quality by making the ablation effect tissue-specific through pulsed electric field ablation. The ablation threshold varies by tissue type, allowing selective destruction of pulmonary artery smooth muscle cells while preserving adjacent tissues like coronary arteries and phrenic nerves. This is achieved by delivering electric pulses that reach the ablation threshold for target tissues but remain below the threshold for surrounding structures.
Solution Approach 2:
The patent utilizes parameter changes by controlling the electric field parameters (voltage, pulse duration, frequency) to achieve tissue-specific ablation. By adjusting these parameters, the system can selectively ablate pulmonary artery tissues while maintaining safety margins for adjacent critical structures, resolving the contradiction between effective ablation and tissue protection.
2Reliability
If traditional ablation methods are used, then treatment of pulmonary arterial hypertension can be achieved, but the operation time is extended and ablation speed is slow
Solution Approach 1:
The patent employs periodic action through pulsed electric field ablation, where high-voltage electric pulses are delivered in rapid succession (milliseconds or less). This periodic delivery of energy achieves extensive myocardial injury and effective pulmonary artery ablation much faster than continuous traditional ablation methods, thereby improving ablation speed while maintaining treatment effectiveness.
3Reliability
If heat conduction-based ablation is used, then coagulation necrosis can be achieved, but the extracellular matrix is damaged and adjacent tissues are affected
Solution Approach 1:
The patent replaces the thermal/mechanical system of heat conduction-based ablation with an electrical system (pulsed electric field ablation). This substitution allows for selective cell membrane disruption through electropermeabilization while preserving the extracellular matrix and surrounding tissue structure, thereby maintaining tissue integrity while achieving effective ablation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The pulse ablation catheter enables precise and rapid tissue ablation with reduced risk to adjacent structures, offering a safer and more effective treatment for pulmonary arterial hypertension by maintaining tissue integrity and avoiding damage to critical areas.
Implementation Method 1
Pulsed electric field ablation refers to the action of high-voltage electric pulses on phospholipid bilayer of cell membrane in a short time, which leads to the formation of transmembrane potential, resulting in unstable potential, irreversible penetrating damage to cell membrane
Data Source
AI summary
A pulse ablation catheter for treating pulmonary arterial hypertension includes an ablation catheter part and an energy platform, where the ablation catheter part includes a movable outer sheath tube, an ablation catheter, a functional guide core, a pulse ablation part and an operating part; the operating part controls the pulse ablation part to slide axially on the functional guide core in a center of the ablation catheter, and controls strip-shaped arches in a middle of the pulse ablation part to arch or fold in a circumferential direction so as to perform pulse ablation through pulse electrode sheets and the energy platform. The pulse ablation catheter for treating pulmonary arterial hypertension of the application performs pulse ablation through the pulse ablation catheter with controllable frequency and ablation end shape to treat pulmonary arterial hypertension.