Pulse Electroporation Ablation System for Imperfect Wall Apposition
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Solution Overview
Problem
Existing ablation catheters based on thermal ablation face challenges with low success rates due to poor wall apposition, and increasing overall ablation energy leads to excessive patient stimulation and uneven tissue ablation.
Innovation Solution
An ablation system with unequal average current densities in its conductive parts, utilizing pulse ablation energy to achieve irreversible electroporation for non-thermal tissue ablation, allowing for precise ablation depth and range without heat conduction, and reducing the need for perfect wall apposition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If thermal ablation is used to increase ablation range and depth, then ablation effectiveness is improved, but patient stimulation becomes excessive and tissue ablation becomes uneven
Solution Approach 1:
The patent changes the fundamental parameter of ablation mechanism from thermal to non-thermal (electroporation). By using pulse electric fields to cause irreversible electroporation of cell membranes rather than thermal heating, the system achieves precise control over ablation depth and range without the harmful effects of excessive patient stimulation and uneven tissue ablation associated with thermal methods
Solution Approach 2:
The patent replaces the thermal ablation mechanism (heating system) with an electroporation mechanism (electric field system). Instead of using thermal energy to denature and necrose tissue, the system uses controlled electric pulses to create irreversible pores in cell membranes, achieving ablation without the harmful thermal effects
2Reliability
If thermal ablation is used, then tissue ablation can be achieved, but wall apposition requirements become excessively high
Solution Approach 1:
The patent replaces thermal conduction-based ablation with electric field-based electroporation. This substitution eliminates the need for tight wall apposition because electric fields can penetrate tissue without requiring direct contact or close proximity, thereby reducing operational complexity while maintaining ablation success rate
Solution Approach 2:
The patent changes the physical mechanism from thermal conduction (requiring contact) to electric field penetration (not requiring contact). By using pulse electric fields that can penetrate through tissue barriers, the system achieves reliable ablation without the excessive wall apposition requirements of thermal methods
3Manufacturing precision
If pulse ablation with unequal current densities is used, then ablation precision is improved, but device complexity increases
Solution Approach 1:
The patent applies local quality by creating non-uniform current density distribution across different regions of the ablation element. By designing conductive parts with varying geometries, materials, or configurations, the system achieves precise control over where and how deeply ablation occurs, allowing targeted treatment while limiting exposure to surrounding healthy tissues
Solution Approach 2:
The patent employs asymmetry in the design of conductive parts to generate unequal current densities. By using asymmetric geometries or positioning conductive elements at different distances from the target tissue, the system creates deliberate current density variations that enable precise ablation control without requiring complex active regulation mechanisms
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides efficient and rapid tissue ablation with minimal patient stimulation, achieving transmural ablation even with imperfect wall apposition and avoiding damage to adjacent tissues.
Implementation Method 1
uses the pulse electric field to cause irreversible electrical breakdown (irreversible electroporation) of the cell membrane, leading to cell apoptosis
Implementation Method 2
adopts the pulse ablation method, which uses the pulse electric field to cause irreversible electrical breakdown (irreversible electroporation) of the cell membrane
Data Source
Figure 1~7
Figure 8~13
Figure 14~15B
AI summary
The application provides an ablation system, which comprises a support body and an ablation part, at least part of the ablation part is arranged on the support body, the ablation part comprises a first conductive part and a second conductive part, the first conductive part and the second conductive part are used to form a loop to transmit pulse ablation energy, their polarities are opposite, and the average current densities of the first conductive part and the second conductive part are not equal.