Pulsed Magnetic Field Coil Control for Mitochondrial Therapy
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Solution Overview
Problem
Current magnetic field treatments for diseases are limited by the need for specific intensity and frequency settings for each targeted disease, and existing technologies do not effectively utilize modulated frequency and weak magnetic fields for therapeutic benefits.
Innovation Solution
A magnetic field generation device and method using a coil and power supply to apply pulsed and frequency-modulated current, with a magnetic field intensity of 60 mG to 3000 mG, and frequency modulation within 1 Hz to 8 Hz, to induce mitophagy and improve mitochondrial function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a constant frequency magnetic field is applied to treat diseases, then the treatment can be simplified, but the therapeutic effectiveness is limited
Solution Approach 1:
The patent applies frequency modulation to the magnetic field, transforming it from a static constant frequency field to a dynamic varying frequency field. The frequency is modulated according to specific patterns (e.g., sinusoidal modulation) to enhance therapeutic effects on mitochondria-related diseases while maintaining operational simplicity through automated control systems.
2Strength
If a strong magnetic field is used for treatment, then the magnetic field intensity is sufficient, but it may cause harmful effects on the living body
Solution Approach 1:
The patent employs pulsed magnetic field application with specific duty cycles and interval patterns rather than continuous strong magnetic fields. The magnetic field is applied in periodic pulses with controlled duration and intensity, allowing tissue recovery periods between pulses, thereby achieving therapeutic effects while minimizing harmful thermal accumulation and cellular stress.
3Reliability
If the magnetic field frequency is modulated to improve therapeutic effects, then the treatment efficacy increases, but the device complexity increases
Solution Approach 1:
The patent replaces complex mechanical frequency adjustment mechanisms with electronic frequency modulation circuits. The frequency modulation is achieved through electronic signal processing and control systems that can dynamically adjust the magnetic field frequency without mechanical moving parts, thereby reducing device complexity while maintaining therapeutic efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively induces mitophagy, reducing mitochondrial mass and improving mitochondrial membrane potential, demonstrating therapeutic potential for mitochondria-related diseases such as Parkinson's and depression.
Implementation Method 1
a power supply, wherein the power supply is configured to apply pulsed and frequency-modulated current to the coil
Data Source
AI summary
A problem is to provide a magnetic field generation device and magnetic field irradiation method that are useful to a living body. This magnetic field generation device includes a coil and a power source. The problem can be solved by the magnetic field generation device of which the power source can apply, to the coil, an electric current that is pulsed and that has frequency fluctuation, a maximum value of a generated magnetic field being 60 mG to 3000 mG.