Pumpkin Seed Oil Sterol Composition for BPH Treatment
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Solution Overview
Problem
Current treatments for benign prostatic hyperplasia (BPH) are either slow-acting, have significant side effects, or require invasive procedures, and botanical drugs often have complex compositions and unclear mechanisms, failing to effectively and rapidly address the condition.
Innovation Solution
A method to obtain a sterol composition from pumpkin seed oil, comprising specific weight percentages of cholesterol, campesterol, β-sitosterol, stigmasterol, ergosta-7,22-dien-3β-ol, lanosterol, and cholest-7-en-3β,5α-diol, achieved through saponification and organic solvent extraction, which inhibits 5α-reductase and regulates genetic expressions related to BPH without hormonal side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If western drug therapy is used to treat BPH, then therapeutic effects are achieved, but the treatment duration is long and side effects are significant
Solution Approach 1:
The patent extracts and concentrates the active sterol components from pumpkin seed oil to create a purified sterol composition. This extraction process isolates the therapeutic agents (sterols like beta-sitosterol, stigmasterol, and campesterol) from the raw oil, creating a more potent and concentrated treatment that achieves therapeutic effects faster while reducing the need for long-term administration.
2Reliability
If western drug therapy is used to treat BPH, then therapeutic effects are achieved, but harmful side effects occur
Solution Approach 1:
The patent changes the chemical composition parameters by using saponification to convert triglycerides into sterols and fatty acids, then selectively extracting the sterol fraction. This parameter change transforms the raw pumpkin seed oil into a purified sterol composition with enhanced therapeutic properties and reduced side effects, as the sterol components act through different mechanisms than conventional western drugs.
3Ease of operation
If operative therapy is used to relieve obstruction in severe BPH, then obstruction is relieved, but body damage and complications occur
Solution Approach 1:
The patent employs a natural, biodegradable sterol composition derived from pumpkin seed oil as a non-invasive treatment alternative. This organic therapy acts as a temporary but effective solution that reduces prostate enlargement and improves urinary flow without causing permanent body damage or surgical complications, allowing patients to avoid invasive operative procedures.
4Adaptability or versatility
If botanical drugs are used to treat BPH, then treatment is provided, but composition is complex and mechanism is unclear
Solution Approach 1:
The patent segments the complex botanical mixture into distinct sterol components through saponification and selective extraction. By separating the therapeutic sterols (beta-sitosterol, stigmasterol, campesterol, etc.) from other oil components, the invention creates a simplified, well-defined composition with clear active ingredients and understood mechanisms of action, while maintaining the versatility of botanical treatment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sterol composition effectively alleviates and treats BPH by inhibiting testosterone conversion to dihydrotestosterone, reducing prostate weight and index, and regulating androgen receptor and growth factor expressions, offering a rapid and safe treatment option.
Implementation Method 1
processing the pumpkin seed oil successively with saponification and organic solvent extraction
Implementation Method 2
processing the pumpkin seed oil successively with saponification and organic solvent extraction
Implementation Method 3
washing the extraction liquid, drying and crystallizing; and obtaining the sterol composition in the pumpkin seed oil
Data Source
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AI summary
A sterol composition in pumpkin seed oil and an application thereof, and a drug for treating benign prostatic hyperplasia are provided, which relate to a technical field of medicine. The sterol composition in the pumpkin seed oil includes components by weight percentage of: 0.2-2wt% cholesterol, 0.5-5wt% campesterol, 1.5-5wt% β-sitosterol, 15-40wt% stigmasterol, 20-40wt% ergosta-7,22-dien-3β-ol, 5-10wt% lanosterol, and 15-30wt% cholest-7-en-3β,5α-diol. The sterol composition in the pumpkin seed oil is a pumpkin phytosterol composition extracted from the pumpkin seed oil. Through combining the phytosterol components and controlling a proportion among the components, effects of alleviating and treating prostate diseases are achieved, especially for the benign prostatic hyperplasia.