Purified Pentagalloyl Glucose Delivery for Aneurysm Stabilization

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Solution Overview

Problem

Current treatments for aneurysms are limited to invasive surgical techniques, which carry risks and may not provide a permanent solution, and there is a need for less invasive, safer methods to stabilize the structural architecture of affected organs and tissues.

Innovation Solution

The development of a composition comprising pentagalloyl glucose (PGG) or its analogues, which can be administered to stabilize the structural architecture of organs and tissues affected by degenerative conditions such as aneurysms, using devices like catheters with balloons to deliver the therapeutic agent directly to the aneurysm.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If invasive surgical techniques are used to treat aneurysms, then the aneurysm can be repaired or replaced, but the patient faces surgical risks and possible post-surgery complications

Engineering Contradiction:

Improveaneurysm repair effectivenessVSAvoidsurgical complications

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces mechanical surgical intervention with a chemical/biological solution by delivering PGG (pentagalloyl glucose) that crosslinks elastin proteins through chemical bonding, stabilizing the vascular structure without physical surgery

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces PGG as an intermediary substance that mediates between the degraded elastin structure and the desired stable vascular architecture, facilitating repair through crosslinking rather than direct surgical manipulation

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If invasive surgical techniques are used to treat aneurysms, then the aneurysm can be repaired, but the treatment may not provide a permanent solution as grafts can loosen and dislodge

Engineering Contradiction:

Improveaneurysm repair effectivenessVSAvoidgraft durability

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent changes the fundamental parameter of vascular repair from mechanical graft insertion to molecular-level crosslinking of elastin proteins, creating a permanent structural stabilization that integrates with native tissue rather than being a separate implantable component

Inventive Principle:

Principle #35Parameter changes

3Reliability

If invasive surgical procedures are performed on deep brain aneurysms, then the aneurysm can be treated, but the danger may outweigh the benefits leaving little treatment options

Engineering Contradiction:

Improveaneurysm treatment effectivenessVSAvoidtreatment accessibility

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces complex mechanical surgical procedures required for deep brain aneurysm access with a minimally invasive delivery system that can be introduced through small catheters, eliminating the need for open craniotomy or complex endovascular navigation

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

4Reliability

If current surgical treatments are used, then lives can be saved, but device-related complications such as thrombosis, leakage, or failure can occur

Engineering Contradiction:

Improvepatient survivalVSAvoiddevice complications

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent enables the vascular tissue to self-repair through the action of PGG crosslinking elastin proteins, eliminating the need for foreign devices that could cause thrombosis, leakage, or mechanical failure

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The use of PGG stabilizes the vascular structure by cross-linking elastin proteins, potentially preventing the growth and rupture of aneurysms, offering a less invasive and safer treatment option compared to traditional surgical methods.

Implementation Method 1

PGG may be delivered to a patient to treat an aneurysm... PGG stabilizes the vascular structure by cross-linking elastin proteins

Methodology Applied

Scientific EffectCross-linking:

Data Source

PatentUS20250288297A1Purified pentagalloyl glucose and devices for delivery

Publication Date: 2025.09.18 NECTERO MEDICAL INC

AI summary

Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.