Pyrazole Compound Controls Efflux Multidrug Resistant Plant Fungi
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Solution Overview
Problem
Efflux type multidrug resistant fungi have developed resistance to plant disease control agents by acquiring the ability to export these agents outside of cells, making existing control methods ineffective.
Innovation Solution
A method involving the application of a pyrazole compound represented by a specific formula to plants or soil to control efflux type multidrug resistant plant diseases, particularly targeting fungi with resistance derived from membrane transporter overexpression or gene mutation, effectively inhibiting respiratory and sterol biosynthesis inhibitors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional plant disease control agents are used, then control efficacy is initially good, but fungi develop resistance through efflux pump overexpression making the agents ineffective
Solution Approach 1:
The patent applies parameter changes by using a pyrazole compound with specific chemical structure parameters (formula 1) that differs from conventional control agents. This structural parameter change allows the compound to bypass the efflux pump recognition mechanism, maintaining control efficacy against resistant fungi without triggering resistance development.
Solution Approach 2:
The pyrazole compound acts as an intermediary substance that interferes with the efflux pump function. By introducing this new chemical mediator with different molecular characteristics, the compound can enter fungal cells and inhibit growth without being actively transported out by the overexpressed membrane transporters.
2Adaptability or versatility
If fungi overexpress membrane transporters to export control agents, then resistance to multiple drugs is acquired, but this creates a new target for selective inhibition
Solution Approach 1:
The patent extracts the specific vulnerability created by efflux pump overexpression and targets it directly. By designing a pyrazole compound that is not a substrate for these transporters, the invention exploits the fact that the fungi's resistance mechanism has made them selectively vulnerable to agents that bypass this export system.
3Ease of operation
If existing control methods are applied to efflux type multidrug resistant fungi, then application is simple, but control efficacy is lost due to resistance
Solution Approach 1:
The patent maintains ease of operation by using a chemical compound application similar to conventional methods, while the changed chemical parameters of the pyrazole compound restore reliability. The compound can be applied through standard agricultural practices, but its unique structure ensures it is not pumped out by resistant fungi, regaining control efficacy.
Data Source
AI summary
The present invention provides a method for controlling efflux type multidrug resistant plant diseases showing an excellent efficacy against efflux type multidrug resistant plant diseases, said method comprising a step of applying an effective amount of a pyrazole compound represented by formula (1): to a plant or soil where the plant grows.