Pyrazole Compound Design for Broad-Spectrum Herbicidal Activity and Crop Safety
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Solution Overview
Problem
Current herbicides face challenges such as growing weed resistance, limited efficacy, and environmental concerns, necessitating the development of new herbicides with broader activity spectra and improved safety for crops.
Innovation Solution
A novel pyrazole compound with a specific structure, containing at least two pyrazole rings, is synthesized through molecular design and optimization, offering enhanced herbicidal activity and safety for crops by targeting a broad spectrum of weeds without harming economically important crops.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pyrazole compounds are used as herbicides, then some herbicidal activity is achieved, but the safety for crops is poor and the activity spectrum is limited
Solution Approach 1:
The patent modifies the chemical structure parameters of pyrazole compounds by introducing specific substituents (halogen atoms at defined positions, ester groups with particular chain lengths, and heteroatom configurations) to optimize the balance between crop safety and herbicidal activity spectrum. The systematic variation of R1-R5 groups allows tuning of molecular properties to achieve both selectivity and broad-spectrum efficacy.
Solution Approach 2:
The invention creates composite molecular structures combining multiple pyrazole rings with diverse functional groups (halogens, esters, heteroatoms) to generate compounds that exhibit both high crop safety and broad herbicidal activity. The composite structure integrates electron-withdrawing and electron-donating groups to achieve optimal biological activity and selectivity profiles.
2Reliability
If herbicides are applied to control weeds, then weed control efficacy is achieved, but weed resistance develops over time
Solution Approach 1:
Instead of developing more potent versions of existing herbicides, the patent inverts the approach by creating compounds with novel mechanisms of action through unique pyrazole-based structures. This structural inversion targets different biochemical pathways in weeds, thereby maintaining efficacy while circumventing resistance mechanisms that have developed against conventional herbicides.
3Productivity
If new herbicides are developed to address resistance and broaden activity, then efficacy and spectrum improve, but environmental safety concerns increase
Solution Approach 1:
The patent applies local quality by introducing specific functional groups at particular positions on the pyrazole rings to enhance herbicidal activity at the target site while minimizing systemic environmental impact. The localized placement of halogen atoms and ester groups optimizes binding affinity to weed enzymes without proportionally increasing environmental persistence or non-target toxicity.
Data Source
AI summary
The present invention relates to the technical field of pesticides, particularly relates to a pyrazole compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. A pyrazole compound of formula (I) or a salt thereof: wherein, R1 represents hydrogen or C1-C4 alkyl; R2 represents C1-C3 alkyl; R3 represents C1-C6 linear chain or cyclic group containing one or more heteroatoms selected from O, S, and N; R4 represents C1-C3 alkyl or halogen; R5 represents pyrazole ring or pyrazole ring substituted with one or more groups selected from alkyl, alkoxyl, halogen, halogenated alkyl, amino, and nitro. The pyrazole compound is an excellent herbicide with broad spectrum biological activity and outstanding safety for crops.