Pyrazole Derivatives for Low-Rate Pest Control
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Solution Overview
Problem
Current pyrazole derivatives for pest control lack efficacy at low application rates and have limited spectrum against resistant pest strains.
Innovation Solution
Development of specific pyrazole derivatives with structures defined by formulas (I) and (II), incorporating various substituents, which exhibit enhanced insecticidal, acaricidal, and molluscicidal properties through specific synthetic methods, allowing for effective pest control at lower application rates.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current pyrazole derivatives are used for pest control, then pest control function is provided, but efficacy at low application rates is insufficient and spectrum against resistant pest strains is limited
Solution Approach 1:
The patent applies parameter changes by systematically varying substituents at specific positions (R1 at position 5, R2 at position 4, Y1/Y3 at positions 2/6) of the pyrazole core structure. This includes changing molecular weight, hydrophobicity, and steric properties through different alkyl, haloalkyl, and functional group combinations, resulting in compounds with enhanced efficacy at lower application rates
Solution Approach 2:
The invention creates composite molecular structures by combining the pyrazole core with diverse substituent patterns including fluorinated alkyl groups, cyano substituents, and various carbonyl-containing groups. These composite structures synergistically improve both efficacy and spectrum of activity against resistant pest strains
2Adaptability or versatility
If current pyrazole derivatives are used for pest control, then basic pest control function is provided, but spectrum against resistant pest strains is limited
Solution Approach 1:
The patent achieves universality by designing a pyrazole core structure that can simultaneously target multiple pest types (insects, mites, nematodes) and overcome various resistance mechanisms. The substituent patterns are optimized to provide broad-spectrum activity while maintaining high efficacy against specific resistant strains through multiple modes of action
Data Source
AI summary
Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, molluse and nematode pests.