Pyrethroid MGK 264 Synergist Formulation for Parasite Control
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Solution Overview
Problem
Existing formulations for controlling parasites like fleas, ticks, and mosquitoes on animals using pyrethrins and pyrethroids are not effective for a duration of at least three weeks, often cause skin irritation, and require large amounts of active compounds, leading to compatibility issues with animals and the environment.
Innovation Solution
Compositions combining pyrethroids or pyrethrins with MGK 264 in a weight ratio of at least 1:20, along with other active compounds and auxiliaries, to create liquid formulations that are skin-friendly, environmentally compatible, and provide long-term parasiticidal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pyrethroids or pyrethrins are used in conventional formulations, then parasiticidal activity is achieved, but skin irritation occurs and long-term action is insufficient
Solution Approach 1:
The patent changes the chemical parameters by introducing MGK 264 as a synergist compound with specific molecular structure (a piperidine derivative), which modifies the overall formulation properties. This synergist enhances the parasiticidal activity while reducing the irritant effects of pyrethroids through chemical interaction at the molecular level
Solution Approach 2:
The patent creates a composite formulation by combining pyrethroids or pyrethrins with MGK 264 in specific weight ratios (at least 1:20). This composite approach allows the synergist to modulate the biological activity and skin compatibility of the pyrethroid components, achieving both efficacy and safety
2Reliability
If conventional formulations are used to achieve parasiticidal effect, then activity is obtained, but the duration of action is short (less than three weeks)
Solution Approach 1:
The patent modifies the temporal parameter of action duration by introducing MGK 264, which has persistent biological activity. The synergist extends the effective concentration of the parasiticidal formulation on the animal skin, maintaining therapeutic levels for at least three weeks through sustained release and metabolic stabilization
Solution Approach 2:
The patent achieves continuous parasiticidal action by combining pyrethroids with MGK 264, where the synergist maintains active compound levels on the skin surface over extended periods. This continuity ensures ongoing protection against parasites without requiring frequent reapplication, achieving at least three weeks of effective action
3Reliability
If large amounts of active compounds are used to achieve acceptable biological action, then efficacy is improved, but compatibility with target animal and environment deteriorates
Solution Approach 1:
The patent optimizes the concentration parameter by introducing MGK 264 as a synergist that enhances the biological activity of pyrethroids. This allows reduction of the pyrethroid content in the formulation while maintaining or improving parasiticidal efficacy, thereby reducing toxicity and environmental impact
Solution Approach 2:
The patent creates a composite formulation where MGK 264 acts as a bioenhancer that increases the potency of pyrethroids. This composite approach enables use of lower amounts of pyrethroid active compound to achieve the same biological effect, improving compatibility with target animals and the environment
4Reliability
If pyrethroids are combined with synergists in conventional ratios (1:5 to 1:20), then activity improvement is achieved, but maximum improvement requires high synergist amounts
Solution Approach 1:
The patent optimizes the ratio parameter between pyrethroid and MGK 264, establishing that a weight ratio of at least 1:20 provides effective synergism. This ratio optimization balances the quantity of synergist needed with the desired activity improvement, avoiding excessive synergist use while achieving maximum efficacy
Data Source
AI summary
The present invention relates to novel skin-friendly dermally applicable liquid formulations comprising a pyrethrin or pyrethroid and MGK 264 in a ratio of at least 1:20 and a further insecticide, preferably from the group of the neonicotinoids, for controlling parasitic arthropods on animals.