Pyrethroid Spray Formulation for Uniform Skin Coverage
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current topical permethrin treatments for conditions like scabies are cumbersome due to thick cream consistency, requiring massage for uniform application and leading to issues with patient compliance and efficacy.
Innovation Solution
A propellant-free sprayable pharmaceutical composition of pyrethroid with a specific viscosity and particle size, allowing for uniform and consistent delivery using a Bag-on-Valve system, facilitating easy and even coverage of the body surface without the need for manual massage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If thick cream formulation is used, then the pyrethroid can be delivered in a stable form, but it requires manual massage for uniform application and reduces patient compliance
Solution Approach 1:
The patent changes the physical state parameter of the pyrethroid formulation from thick cream to sprayable liquid form. This parameter change enables uniform distribution through spraying while maintaining delivery stability, eliminating the need for manual massage and improving patient compliance.
Solution Approach 2:
The patent utilizes spray technology (pneumatic/hydraulic principle) to deliver the pyrethroid formulation. The spray mechanism atomizes the liquid formulation into fine particles that can be evenly distributed over the treatment area, replacing the manual application method and achieving uniform coverage without massage.
2Manufacturing precision
If thick cream is applied to cover hard-to-reach places, then complete coverage can be achieved, but it consumes excessive product and reduces patient compliance
Solution Approach 1:
The spray delivery system atomizes the pyrethroid formulation into fine mist particles that can penetrate and coat hard-to-reach areas efficiently. This method achieves complete and uniform coverage with significantly reduced product consumption compared to thick cream application, as the spray deposits material more precisely and evenly.
Solution Approach 2:
The formulation is delivered as discrete spray particles rather than a continuous thick cream mass. This segmentation allows the product to reach into crevices and hard-to-access areas more effectively, ensuring complete coverage while using less total product.
3Ease of operation
If propellant is added to enable spray delivery, then uniform coverage is improved, but inhalation risk and formulation complexity increase
Solution Approach 1:
The patent extracts and eliminates the propellant component from the spray formulation. Instead of using propellants to achieve spray delivery, the formulation relies on alternative mechanisms (such as pump-driven or pressure-driven spray systems) that do not require inhalable propellants, thereby maintaining application ease while removing the inhalation hazard.
Solution Approach 2:
The patent introduces an intermediary delivery mechanism (such as a pump or pressure system) that replaces the propellant's function of propelling the formulation. This intermediary enables spray delivery and uniform coverage without using inhalable propellants, resolving the contradiction between ease of operation and inhalation safety.
Data Source
AI summary
Sprayable compositions comprising a pyrethroid, a viscosity building agent, an emulsifier or surfactant, and an emollient are provided. The compositions have a viscosity that allows for delivery of the spray from a pressurized container such that the pyrethroid is administered in a consistent amount that uniformly covers the body of a subject. This obviates the need to rub the composition into the skin. In preferred embodiments, the pyrethroid is permethrin; the viscosity building agent is selected from the group consisting of carbomers, xanthan gum, or a combination thereof; the emulsifier or surfactant is selected from the group consisting of glyceryl mononstearate, PEG40 hydrogenated castor oil, cholesterol, steareth-10, steareth-20, and combinations thereof; and the emollient is selected from the group consisting of C12-C15 alkyl benzoates, diisopropyl adipate, silicon oil, mineral oil, or any combination thereof.