Pyridazinol Herbicidal Compositions for Resistant Weed Control
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Solution Overview
Problem
Existing herbicides face challenges with weed resistance, limited efficacy, and environmental safety, necessitating the development of new herbicides with high efficiency, selectivity, and diverse mechanisms of action.
Innovation Solution
A pyridazinol compound and its derivatives, characterized by specific substituents and structures, are formulated into herbicidal compositions that exhibit high herbicidal activity and crop safety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing herbicides are used, then weed control is achieved, but weed resistance develops and efficacy decreases
Solution Approach 1:
The patent modifies the chemical structure of pyridazinone compounds by changing parameters such as substituting the carbonyl group (C=O) with a hydroxyl group (OH) at the 4-position to create pyridazinol compounds. This structural parameter change results in a new mechanism of action that overcomes weed resistance to existing herbicides while maintaining high herbicidal efficacy
Solution Approach 2:
The invention creates composite herbicidal compositions by combining pyridazinol compounds with other herbicides or adjuvants. This composite approach enhances the overall herbicidal effect and helps manage resistance by targeting multiple physiological pathways simultaneously
2Reliability
If herbicide application is increased to overcome resistance, then weed control improves, but environmental safety and crop safety deteriorate
Solution Approach 1:
The pyridazinol compounds achieve high herbicidal activity at low application rates due to their novel mechanism of action. This allows effective weed control without exceeding environmental safety thresholds or causing crop phytotoxicity, resolving the contradiction between efficacy and safety
Solution Approach 2:
The patent develops new chemical entities with short residual activity periods that degrade quickly in the environment. This approach provides effective weed control when needed while minimizing long-term environmental accumulation and safety concerns
3Adaptability or versatility
If new herbicides with different mechanisms of action are developed, then weed resistance is overcome, but development complexity and cost increase
Solution Approach 1:
The patent systematically explores different substituent patterns on the pyridazinol core structure (varying R1, R2, R3, R4, R5, R6, R7, R8 groups) to create a series of analogs with potentially different mechanisms of action. This segmented approach allows efficient discovery of multiple modes of action from a single core structure
Solution Approach 2:
The pyridazinol core structure serves as a universal platform that can be modified with various substituents to achieve multiple functions and mechanisms of action. This multi-functional approach allows a single chemical series to address multiple weed resistance issues without requiring entirely separate development programs
Data Source
AI summary
The invention belongs to the technical field of agricultural chemicals, and in particular relates to a pyridazinol compound represented by the Formula I, a derivative, preparation method, herbicidal composition and use thereof. The compound, derivative and herbicidal composition thereof have very high herbicidal activity and selectivity, and are safe for crops,