Pyridine Compounds Overcoming Insect Resistance
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Solution Overview
Problem
There is an acute need for new pesticides due to the development of resistance in insects to current pesticides, particularly for controlling aphids and other sucking insects, as existing pesticides are no longer effective.
Innovation Solution
Development of specific compounds of formula I, which include various substituents and heterocyclic rings, prepared through different synthetic methods, offering new modes of action against insects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pesticides are used, then initial pest control effectiveness is achieved, but insect resistance develops over time rendering them ineffective
Solution Approach 1:
The patent develops entirely new chemical compounds with different molecular structures (pyridine, pyrimidine, triazine rings with specific substituent patterns) compared to existing pesticides. This fundamental parameter change in chemical structure enables new modes of action that bypass resistance mechanisms developed against conventional pesticides, restoring effective pest control.
2Reliability
If new pesticide compounds are developed, then resistance issues are overcome, but development complexity and time increase
Solution Approach 1:
The patent employs a systematic approach by dividing the pesticide development into distinct chemical scaffold categories (pyridine, pyrimidine, triazine rings) with standardized substituent positions. This segmentation allows for organized exploration of structure-activity relationships, making the complex development process more manageable and systematic.
Solution Approach 2:
The patent systematically varies specific parameters such as substituent types (halogens, alkyl groups, cyano groups), their positions on the heterocyclic rings, and ring nitrogen configurations to optimize activity while managing complexity. This structured parameter variation enables efficient navigation of the chemical space.
3Reliability
If new pesticide compounds are synthesized, then new modes of action are achieved, but manufacturing process complexity increases
Solution Approach 1:
The patent describes multi-step synthesis routes where intermediate compounds are prepared and characterized before final assembly. This preliminary action allows for optimization of each synthetic step independently, purification of intermediates to ensure quality, and planning of the overall manufacturing process before full-scale production.
Solution Approach 2:
The synthesis is divided into discrete chemical transformations with specific reagents and conditions for each step. This segmentation of the manufacturing process into manageable stages (ring formation, substituent introduction, purification) facilitates easier implementation and quality control in production.
Data Source
AI summary
The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. Novel pyridine compounds for use in controlling pests are disclosed.