4-Pyridinyl Formamide Herbicides for Resistant Weed Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
The increasing resistance of weeds to existing herbicides, particularly ALS inhibitors and ACCe inhibitors, necessitates the development of new herbicides with higher efficiency, safety, and selectivity for crops like wheat and rice, while addressing environmental concerns.
Innovation Solution
A 4-pyridinyl formamide compound or derivative thereof, characterized by specific substituents, exhibits excellent herbicidal activity and crop safety, offering selectivity for key crops such as wheat and rice.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing herbicides (ALS inhibitors and ACCe inhibitors) are used for weed control, then weed control effect is achieved, but weed resistance increases
Solution Approach 1:
The patent changes the chemical structure parameters by introducing a 4-pyridinyl formamide core structure with specific substituents (X, Y, M, R1-R6 groups), creating a new herbicide class that differs fundamentally from existing ALS and ACCe inhibitors. This structural parameter change enables the compound to overcome weed resistance while maintaining herbicidal activity
Solution Approach 2:
The patent creates a composite molecular structure combining a pyridinyl ring system with formamide linkage and various substituent groups (halogen, cyano, nitro, alkyl, aryl, heteroaryl groups). This composite structure integrates multiple functional groups that work synergistically to achieve both weed control and crop safety, addressing the resistance problem through structural complexity
2Reliability
If new herbicides are developed to overcome resistance, then herbicidal activity is improved, but crop safety may be compromised
Solution Approach 1:
The patent applies local quality by introducing specific substituent groups at defined positions on the pyridinyl formamide core structure. Different substituents (electron-withdrawing groups like halogen, cyano, nitro at X and Y positions; various alkyl, aryl, heteroaryl groups at M and R1-R6 positions) create localized electronic and steric effects that enhance herbicidal activity while maintaining selectivity for crop safety
Solution Approach 2:
The patent creates a dynamic series of derivatives by varying substituents at multiple positions (X, Y, M, R1-R6) on the core structure. This allows optimization of the balance between herbicidal activity and crop safety through systematic structural modification, enabling selection of compounds with desired activity-safety profiles
3Reliability
If herbicide effectiveness is maintained against resistant weeds, then weed control is achieved, but environmental impact increases
Solution Approach 1:
The patent changes chemical parameters by developing a new molecular class with improved metabolic stability and reduced non-target effects. The pyridinyl formamide structure with specific substituents provides enhanced selectivity and reduced environmental persistence compared to conventional herbicides, maintaining effectiveness while reducing harm
Data Source
AI summary
The invention belongs to the technical field of pesticides, and specifically relates to a 4-pyridinyl formamide compound or a derivative thereof, a preparation method therefor, a herbicidal composition and the use thereof. The 4-pyridinyl formamide compound is as represented by formula (I), wherein, X and Y each independently represent nitro, halogen, cyano, formyl, thiocyano, mercapto, etc.; and M represents an unsubstituted or substituted structure (II). The compound, and the derivative and the composition thereof have excellent herbicidal activity and a higher crop safety, and establish good selectivity, especially for key crops such as wheat and rice.