Substituted Pyrimidinium Compounds for Resistant Pest Control

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Solution Overview

Problem

Current pesticidal agents face challenges due to the development of resistance by invertebrate pests such as insects, arachnids, and nematodes, necessitating the need for new compounds with broad-spectrum activity.

Innovation Solution

Substituted pyrimidinium compounds of a specific formula, including their stereoisomers, salts, tautomers, and N-oxides, are developed for use in combating invertebrate pests, offering effective pesticidal activity against difficult-to-control insects, arachnids, and nematodes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing pesticidal agents are used, then initial pest control is effective, but pests develop resistance over time reducing efficacy

Engineering Contradiction:

Improvepesticidal activityVSAvoidlong-term effectiveness

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies parameter changes by developing novel substituted pyrimidinium compounds with modified chemical structures (formula I) that differ from existing pesticidal agents. This structural parameter change creates new modes of action that pests have not developed resistance against, thereby maintaining reliable pesticidal activity while avoiding the resistance problem that plagues long-term use of conventional agents

Inventive Principle:

Principle #35Parameter changes

2Reliability

If new pesticidal compounds are developed to overcome resistance, then activity against resistant pests improves, but the complexity of finding effective compounds increases

Engineering Contradiction:

Improveactivity against resistant pestsVSAvoidcompound structure complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies local quality by introducing specific substituent groups at defined positions on the pyrimidinium core structure (formula I). This localized modification approach allows systematic optimization of pesticidal activity against resistant pests while maintaining a manageable level of overall structural complexity through focused chemical modifications rather than complete structural redesign

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent applies universality by designing the substituted pyrimidinium compounds to exhibit broad-spectrum activity against multiple pest types including insects, arachnids, and nematodes. This multi-functional approach allows a single compound class to address resistance issues across diverse pest populations, reducing the need for multiple specialized compounds and simplifying the overall solution complexity

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS11542280B2Substituted pyrimidinium compounds and derivatives for combating animal pests

Publication Date: 2023.01.03 BASF SE

AI summary

The present invention relates to substituted pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these substituted pyrimidinium compounds and of compositions thereof, for combating and controlling animal pests. Furthermore the invention relates also to pesticidal methods of applying such substituted pyrimidinium compounds.The substituted pyrimidinium compounds of the present invention are defined by the following general formula (I)wherein X, Y, Z, R1, R2, A and R3 are defined as in the description.