Pyripyropene Liquid Concentrate Formulation Stability
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Solution Overview
Problem
Agricultural formulations of pyripyropene derivatives often suffer from low stability due to solvate complex formation, leading to settling or agglomeration, and polyalkoxylated alcohols, while enhancing insecticidal activity, can interfere with solubilization and cause phase separation when used with certain solvents like propylene glycol, which has a favorable toxic profile.
Innovation Solution
A liquid concentrate formulation comprising 0.5-30% pyripyropene derivative, 3-50% propylene glycol, 20-85% alkoxylated aliphatic alcohol, 1-50% C2-C4-alkylene carbonate, and 0.5-20% non-ionic surfactant, ensuring compatibility and stability, preventing phase separation and maintaining insecticidal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If polyalkoxylated alcohols are added to enhance insecticidal activity, then pesticidal efficacy is improved, but phase separation occurs due to incompatibility with propylene glycol solvent
Solution Approach 1:
The patent introduces C2-C4-alkylene carbonates as intermediary substances that mediate between the polyalkoxylated alcohol adjuvant and propylene glycol solvent. These carbonates act as compatibility agents that prevent phase separation while allowing the polyalkoxylated alcohol to maintain its insecticidal activity-enhancing function without direct conflict with the solvent system.
Solution Approach 2:
The formulation creates a composite solvent system combining propylene glycol, C2-C4-alkylene carbonates, and polyalkoxylated alcohols in specific proportions. This composite material approach allows the mixture to exhibit properties that individual components alone cannot achieve, specifically maintaining both high insecticidal activity and long-term storage stability through synergistic interactions.
2Quantity of substance
If solvents with better solubilization capacity are used, then solubility of pyripyropene derivative is improved, but toxic profile becomes unfavorable for agricultural applications
Solution Approach 1:
The patent changes the physical-chemical parameters of the solvent system by using propylene glycol in combination with C2-C4-alkylene carbonates and polyalkoxylated alcohols. This parameter optimization achieves adequate solubility for the pyripyropene derivative while maintaining low toxicity, as the combined solvent system provides enhanced solubilization capacity without the harmful effects of alternative high-performance solvents.
3Quantity of substance
If concentrate formulations are prepared to improve storage density, then formulation concentration is improved, but settling and agglomeration occur during storage
Solution Approach 1:
The C2-C4-alkylene carbonates serve as intermediary substances that prevent solvate complex formation between the pyripyropene derivative and solvent molecules. By disrupting these unfavorable interactions, the carbonates eliminate the driving force for settling and agglomeration, allowing the concentrate formulation to remain stable and homogeneous during prolonged storage while maintaining high active ingredient concentration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation provides stable, optically transparent, and environmentally friendly solutions that remain effective for prolonged storage and upon dilution, offering enhanced pesticidal activity with low toxicity.
Implementation Method 1
This is typically caused by pyripyropene derivative I forming solvate complexes with the solvent that is included in the formulation
Implementation Method 2
e) 0.5 to 20 wt %, based on the total weight of the formulation, of at least one non-ionic surfactant S that is different from the alkoxylated aliphatic alcohol A
Data Source
AI summary
The present invention relates to a liquid concentrate formulation comprising a pyripyropene pesticide of the formula I as defined below and an alkoxylated aliphatic alcohol as an adjuvant. Moreover, the invention relates to the use of the formulations for the treatment of plants and seed and to corresponding methods.