Pyripyropene Emulsifiable Formulation Stability via Heating
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Solution Overview
Problem
Liquid emulsifiable formulations of pyripyropene derivative I exhibit low physical stability upon storage, leading to crystalline material formation and dosage issues, and the use of certain adjuvants can further decrease stability, making it challenging to maintain stability regardless of the starting material used.
Innovation Solution
A method involving dissolving surfactants and pyripyropene derivative I in an aromatic hydrocarbon solvent, followed by heating the solution to at least 40°C to create a stable emulsifiable formulation that remains homogeneous and stable for prolonged storage periods, even at extreme temperatures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If pyripyropene derivative I is solubilized in aromatic hydrocarbon solvent for emulsifiable formulation, then the formulation can be diluted with water to form emulsion, but crystalline material forms upon storage reducing physical stability
Solution Approach 1:
The patent changes the physical state parameter by heating the formulation to 40°C or higher. This temperature parameter change prevents crystalline material formation and maintains physical stability while preserving emulsion formation capability. The heating step transforms the system from a potentially unstable state to a stable homogeneous solution.
Solution Approach 2:
The patent creates a composite system combining pyripyropene derivative I, aromatic hydrocarbon solvent, and surfactant in specific proportions. This composite formulation maintains solubility and prevents crystallization through the synergistic interaction of components, particularly the surfactant which stabilizes the emulsion and prevents precipitation.
2Reliability
If surface active adjuvant is added to enhance insecticidal activity, then bioactivity is improved, but solubilization of pyripyropene derivative I is interfered with decreasing physical stability
Solution Approach 1:
The patent applies temperature parameter change (heating to 40°C or higher) to overcome the solubilization interference caused by adjuvants. This thermal energy input disrupts the unfavorable interactions between adjuvant and pyripyropene derivative, restoring solubility and physical stability while maintaining the adjuvant's bioactivity enhancement function.
Solution Approach 2:
The patent performs preliminary heating treatment during formulation preparation to prevent crystalline material formation before storage. This advance action ensures that the interaction between adjuvant and active ingredient does not lead to precipitation during subsequent storage, maintaining both stability and activity.
3Ease of manufacture
If conventional formulation method is used without heating, then manufacturing is simple, but crystalline material separates causing dosage problems and clogging
Solution Approach 1:
The patent introduces a temperature parameter change (heating to 40°C or higher) as a simple process modification. This single parameter change prevents crystalline material separation, ensuring accurate dosing and preventing clogging, while adding minimal complexity to the manufacturing process.
Solution Approach 2:
The patent applies preliminary heating during the formulation preparation stage to prevent crystallization issues before they occur. This advance treatment ensures that the final formulation remains stable during storage and application, eliminating dosage accuracy problems and clogging risks.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method produces stable liquid emulsifiable formulations that prevent crystalline material formation, ensuring consistent performance and ease of use without stability issues, even after prolonged storage and extreme temperature exposure.
Implementation Method 1
heating the solution to a temperature of at least 40°C
Data Source
AI summary
The present invention relates to a method for producing a liquid non-aqueous emulsifiable formulation comprising a pyripyropene pesticide of the formula (I) as defined below which is dissolved in an aromatic hydrocarbon or hydrocarbon mixture containing surfactants, which stabilize the emulsion upon dilution with water, which method comprises the steps i) and ii) as described hereinafter: i) dissolving the at least one surfactant and the compound of formula (I) in the organic solvent or solvent mixture to obtain a clear solution of the at least one surfactant and the compound of the formula(I); ii) heating the solution to a temperature of at least 40°C.