QMR RF Circuit Harmonic Tuning for Tissue-Specific Stimulation
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Solution Overview
Problem
Existing QMR technologies lack the ability to modulate electric currents effectively based on the type of cells or tissues treated, leading to varying biological effects and potential thermal side effects.
Innovation Solution
An electronic device generating QMR currents with specific harmonic ratios and frequencies, adjustable based on Ohmic load, to optimize biological effects without thermal impact.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If QMR electric currents are applied to different cells or tissues, then different biological effects are induced, but it is difficult to identify and control the parameters that determine these varying effects
Solution Approach 1:
The patent applies parameter changes by systematically varying key electrical parameters (frequency, harmonic spectrum, current amplitude) of QMR waves to induce different biological effects. The invention identifies that specific parameter combinations produce specific cellular responses, enabling controlled modulation of biological outcomes through parameter optimization.
Solution Approach 2:
The patent implements feedback mechanisms by monitoring cellular responses to QMR application and using this information to adjust treatment parameters in real-time. This allows the system to adapt to different cell types and tissue characteristics, optimizing the biological effect while maintaining control over the complexity of parameter management.
2Reliability
If high-frequency electric fields are applied to induce QMR effects, then molecular bonds can be broken and biological responses triggered, but thermal effects may occur that cause tissue damage
Solution Approach 1:
The patent applies local quality by creating highly localized QMR effects at the molecular level while maintaining controlled thermal characteristics. By tuning the frequency and harmonic content of the electric fields, the invention achieves selective molecular resonance and bond breaking in targeted regions without causing widespread thermal damage to surrounding tissues.
Solution Approach 2:
The patent utilizes periodic action through the application of oscillating high-frequency electric fields with specific frequency modulations. The periodic nature of QMR waves allows for cumulative molecular effects while distributing thermal energy over time, preventing excessive localized heating that would cause tissue damage.
3Adaptability or versatility
If QMR waves with different frequencies and harmonic spectra are applied, then different cell pathways can be activated, but the device lacks the capability to modulate currents based on the specific tissue type
Solution Approach 1:
The patent applies universality by designing a multi-functional QMR device capable of treating different cell types and tissue structures with a single system. The invention achieves this through programmable frequency and harmonic spectrum generation, allowing the same device to activate different cellular pathways by simply adjusting treatment parameters rather than requiring specialized equipment for each application.
Solution Approach 2:
The patent implements dynamics through the ability to dynamically adjust frequency, harmonic content, and amplitude parameters during treatment based on real-time monitoring of cellular responses. This dynamic adaptation enables the device to optimize pathway activation for different tissue types while maintaining ease of operation through automated parameter selection algorithms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device modulates QMR currents to achieve desired biological outcomes on different tissues or cells, ensuring safety and efficacy across various treatments.
Implementation Method 1
it was demonstrated by the Applicant that the application of current waves with fundamental frequency higher than 2 MHz and distorted by the presence of harmonics transmits an energy to the molecules on which these current waves are applied that corresponds to the so-called 'molecular resonance', known as the Quantum Molecular Resonance (QMR)
Implementation Method 2
the passage of electric currents, or rather electric fields, through biological tissues, in addition to generating thermal effects, is capable of modifying the distribution of the surface charges in cell membranes. Such variations in the charge distribution can induce modifications of membrane proteins and, among them in particular, the opening or closing of voltage-dependent ion channels
Implementation Method 3
the passage of electric currents, or rather electric fields, through biological tissues, in addition to generating thermal effects
Data Source
AI summary
An electronic device for biomedical use includes a radio frequency circuit which can be powered by a voltage and at least one electrode connected at the output to the radio frequency circuit and applicable to a part of a person's body. The radio frequency circuit is configured to generate as output an electric current wave with fundamental frequency higher than or equal to 2 MHz and distorted by the presence of at least second-order harmonics, wherein the first percentage ratio between the amplitude of the peak of the electric current wave at the second-order harmonic and the amplitude of the peak of the electric current wave at the fundamental frequency is comprised between 20% and 70% when a load around 100 Ohms is applied to the electrode, whereas said first percentage ratio is comprised between 25% and 120% when a load around 830 Ohms is applied to the electrode.