Quadrupole Mass Spectrometer Layout for RF Feedback Accuracy

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Solution Overview

Problem

Existing mass spectrometers face challenges in achieving high throughput and compactness while maintaining measurement accuracy, particularly due to the need for close proximity of control units to minimize noise interference in RF voltage feedback control.

Innovation Solution

The mass spectrometer is modularized with the ionization, mass analysis, and detection units in one housing and the control circuits in another, with noise-resistant signal conversion methods for RF voltage feedback control, including amplification, digital conversion, or insulated transfer of feedback signals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of repair

If the mass spectrometer is modularized with control circuits separated from the mass spectrometry unit to improve maintainability and accessibility, then the ease of repair and ease of operation are improved, but the measurement precision deteriorates due to increased distance between the control unit and the quadrupole mass filter

Engineering Contradiction:
ImprovemaintainabilityVSAvoidmeasurement accuracy
Core Design Contradiction:
Ease of repairVSMeasurement precision

Solution Approach 1:

A resonance circuit is introduced as an intermediary component between the RF control substrate and the quadrupole mass filter. This resonance circuit receives the RF signal from the control circuits and directly applies it to the quadrupole mass filter, effectively bridging the gap created by modularization. The resonance circuit maintains signal integrity and minimizes noise interference despite the physical separation between control circuits and mass spectrometry unit.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If the control unit and quadrupole mass filter are disposed close to each other to maintain feedback control accuracy, then the measurement precision is improved, but the ease of operation and maintainability worsen due to limited accessibility for operators

Engineering Contradiction:
Improvefeedback control accuracyVSAvoidaccessibility
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The mass spectrometer is divided into distinct modular units: a mass spectrometry unit containing the ionization unit, quadrupole mass filter, and mass detection unit, and a separate control unit containing the control circuits. This segmentation allows the mass spectrometry unit to be compact with minimal distance between components for accurate feedback control, while the control unit can be positioned separately for easy accessibility and maintenance.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The resonance circuit serves as a mediator that enables accurate RF signal transmission between the separated control unit and mass spectrometry unit. By placing the resonance circuit within the mass spectrometry unit close to the quadrupole mass filter, the system maintains feedback control accuracy despite the physical separation of modular units.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Volume of moving object

If the mass spectrometer is made compact by reducing the distance between components, then the volume is reduced, but the ease of operation worsens due to limited space for operator access and maintenance

Engineering Contradiction:
Improveapparatus sizeVSAvoidoperator accessibility
Core Design Contradiction:
Volume of moving objectVSEase of operation

Solution Approach 1:

The apparatus is segmented into a compact mass spectrometry unit and a separate control unit. The mass spectrometry unit contains all the space-constrained components (ionization unit, quadrupole mass filter, mass detection unit, and resonance circuit) in a compact arrangement, while the control unit with control circuits is positioned separately, providing adequate space for operator access and maintenance activities.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration enhances maintainability and maintains analytical sensitivity, ensuring a compact and efficient mass spectrometer design without compromising measurement accuracy.

Implementation Method 1

an ionization unit (201) that ionizes an analysis object specimen

Methodology Applied
Scientific EffectIonization: Ionisation

Implementation Method 2

an RF output unit (205) that includes a resonance circuit (108) for superimposingly applying direct current voltage and radio-frequency voltage to the quadrupole mass filter

Methodology Applied
Scientific EffectSuperposition principle:

Data Source

PatentEP4657493A1Mass spectrometer
Publication Date: 2025.12.03 HITACHI HIGH TECH CORP
  • EP4657493A1 patent drawingFigure 1
  • EP4657493A1 patent drawingFigure 2
  • EP4657493A1 patent drawingFigure 3A~3B

AI summary

To provide a mass spectrometer that is compact while improving the maintenance characteristic. A mass spectrometer 40 includes a first housing 206 and a second housing 208 disposed below the first housing, an ionization unit 201, a mass analysis unit 202 including a quadrupole mass filter, a mass detection unit 203, and an RF output unit 205 including a resonance circuit 108 applying radio-frequency voltage to the quadrupole mass filter are disposed in the first housing, a substrate storage unit 204 storing at least a control circuit substrate including an RF control circuit 101 generating a radio-frequency signal and an RF substrate including an RF amplifier 107 amplifying the radio-frequency signal and supplying the amplified radio-frequency signal to the resonance circuit is disposed in the second housing, the ionization unit, the mass analysis unit, and the mass detection unit are disposed in the first housing from a front surface toward a rear surface, and the substrate storage unit is disposed in the second housing on the front surface.