Quenching Agent Neutralizes Toxic Cross-linker Residues in Cell Tissue Gels
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Solution Overview
Problem
Existing cell tissue gels used for surgical applications often rely on toxic cross-linking agents, which can cause histotoxicity and inflammation, especially when used below the dermis.
Innovation Solution
A cell tissue gel is developed that incorporates a matrix molecule cross-linked with a cross-linking agent, along with a quenching agent that binds to the reactive groups of the cross-linking agent, reducing toxicity by minimizing the amount of unreacted reactive groups.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If cross-linking agents are used to form cell tissue gels, then adhesive strength and gel structure are improved, but toxicity to host tissues increases
Solution Approach 1:
The patent uses a quenching agent as an intermediary substance that reacts with unreacted cross-linking agent to neutralize its toxic effects. The quenching agent contains functional groups that specifically bind to reactive groups on the cross-linking agent, converting the harmful substance into a non-toxic form while preserving the beneficial adhesive properties of the gel.
Solution Approach 2:
The patent changes the chemical parameters of the system by introducing a quenching agent that alters the reactivity profile of the cross-linking agent. By controlling the ratio of reactive groups to quenching agent functional groups, the system transforms the toxic cross-linking agent into a safe, non-reactive state while maintaining the desired gel structure and adhesive strength.
2Reliability
If cross-linking agents are used to create tissue gels, then gel formation and binding strength are improved, but histotoxicity and inflammation occur
Solution Approach 1:
The patent converts the harmful toxic byproducts of cross-linking into beneficial neutral substances. The quenching agent reacts with unreacted cross-linking agent and its toxic byproducts to form harmless end products, effectively transforming the harmful chemical reactions into beneficial neutralization processes that eliminate histotoxicity while preserving gel formation.
3Strength
If synthetic cross-linking agents are used, then adhesive performance is improved, but biodegradation into toxic byproducts occurs
Solution Approach 1:
The quenching agent acts as an intermediary that intercepts and neutralizes toxic byproducts generated during the biodegradation of synthetic cross-linking agents. By introducing this intermediary substance, the system prevents the accumulation of harmful degradation products while maintaining the adhesive performance provided by the synthetic cross-linking agent.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of this gel results in reduced toxicity and improved biocompatibility, allowing for safer and more effective tissue adhesion and repair without causing acute or chronic inflammation.
Implementation Method 1
a quenching agent bound to a reactive group of the cross-linking agent, wherein the quenching agent contains a moiety that is capable of reacting with the reactive group of the cross-linking agent
Data Source
AI summary
A cell tissue gel, comprising one or more matrix molecules cross-linked with a cross-linking agent, and a quenching agent bound to a reactive group of the cross-linking agent, wherein the quenching agent contains a moiety that is capable of reacting with the reactive group of the cross-linking agent and the one or more matrix molecules contain one or more functional groups that are capable of cross-linking with the reactive group, the amount of the reactive group of the cross-linking agent being equal to or less than a total amount including the amount of the one or more functional groups and the amount of the moiety.