Quercetin Phospholipid Complexes for Enhanced Bioavailability
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Solution Overview
Problem
Existing methods for utilizing quercetin, a flavonoid with numerous health benefits, face challenges such as low bioavailability, poor absorption, and limited convenience for human and animal subjects.
Innovation Solution
The development of flavonoid compositions that include quercetin or its derivatives, combined with additives like green tea extract, blueberry anthocyanidins, caffeine, omega-3 fatty acids, and ascorbic acid, to enhance bioavailability and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If quercetin is administered in conventional forms, then health benefits are provided, but bioavailability and absorption are limited
Solution Approach 1:
The patent combines quercetin with phospholipids to create a composite formulation that enhances bioavailability. The phospholipid component forms micellar structures that solubilize quercetin, improving its absorption and transport in the gastrointestinal tract while maintaining the health benefits of quercetin.
Solution Approach 2:
The patent modifies the chemical state of quercetin by forming complexes with phospholipids and utilizing micellar solubilization. This changes the physical-chemical parameters of quercetin, including its solubility and stability, thereby enhancing its bioavailability without altering its biological activity.
2Reliability
If quercetin is administered in conventional forms, then health benefits are provided, but absorption is poor
Solution Approach 1:
The patent introduces phospholipids as intermediary substances that facilitate the absorption of quercetin. These phospholipids act as carriers that interact with quercetin molecules, forming soluble complexes that are more easily absorbed by the intestinal lining, thereby improving the ease of absorption while preserving health benefits.
Solution Approach 2:
The patent changes the physical state and solubility parameters of quercetin through phospholipid complexation and micellar formation. This transformation makes quercetin more compatible with the aqueous environment of the gastrointestinal tract, significantly improving its absorption characteristics without compromising its therapeutic effects.
3Device complexity
If conventional quercetin formulations are used, then simplicity is maintained, but convenience for administration is limited
Solution Approach 1:
The patent creates a multi-functional formulation where phospholipids serve multiple purposes: they act as solubilizing agents, absorption enhancers, and stability protectors for quercetin. This universal approach improves administration convenience through enhanced solubility and stability while maintaining relative formulation simplicity by using a single class of compounds for multiple functions.
Data Source
AI summary
Flavonoid compositions containing the flavonoid quercetin and/or derivatives of quercetin are disclosed. The flavonoid compositions are formulated to improve the bioavailability of quercetin. Also provided herein are methods for improving athletic performance, improving cardiovascular health, and aiding in immune response and methods of improving athletic performance, improving bone health, preventing fatigue, reducing recovery time after exercise, countering oxidative stress, and/or boosting energy.